GENETIC ANALYSIS: AN INTEG. APP. W/MAS
2nd Edition
ISBN: 9781323142790
Author: Sanders
Publisher: Pearson Custom Publishing
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Chapter 15, Problem 19P
Provide a description of the mechanistic roles of transcription factors and chromatin-modifying and chromatin-remodeling enzymes in the control of eukaryotic geneexpression.
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Discuss the role of chromatin and modification of chromatin structure in controlling eukaryotic gene expression
Design a transcriptional circuit that regulates the expression of β-galactosidase in a eukaryoticcell, such that the enzyme is produced in the presence of lactose and repressed in the absenceof lactose. Use at least one of the following elements: histone acetyltransferase, histonedeacetylase, chromatin remodeling complex
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Chapter 15 Solutions
GENETIC ANALYSIS: AN INTEG. APP. W/MAS
Ch. 15 - 13.1 Devoting a few sentences to each, describes...Ch. 15 - 13.2 Describe and give an example (real or...Ch. 15 - What is meant by the term chromatin remodeling?...Ch. 15 - 13.4 What general role does acetylation of histone...Ch. 15 - 13.5 Describe the roles of writers, readers, and...Ch. 15 - Outline the roles of RNA in eukaryotic gene...Ch. 15 - 13.7 What are the roles of the Polycomb and...Ch. 15 - Most biologists argue that the regulation of gene...Ch. 15 - Compare and contrast the transcriptional...Ch. 15 - The term heterochromatin refers to heavily...
Ch. 15 - 13.11 Compare and contrast promoters and enhancers...Ch. 15 - 13.12 What are the different chromatin...Ch. 15 - 13.13 Define epigenetics, and provide examples...Ch. 15 - What is one proposed role for lncRNAs?Ch. 15 - 13.17 A hereditary disease is inherited as an...Ch. 15 - Prob. 16PCh. 15 - A gene expressed in long muscle of the mouse is...Ch. 15 - The consequences of four deletions from the region...Ch. 15 - Provide a description of the mechanistic roles of...Ch. 15 - 13.20 A muscle enzyme called ME is produced by...Ch. 15 - 21. A muscle protein in mouse is produced through...
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Describe how methylation and acetylation of the histones changes gene expression in eukaryotes. What groups are added? How do these processes physically affect chromatin structure? Silencing or Enhancing expression?arrow_forwardIdentify the mechanisms of transcriptional,posttranscriptional, and translational control of geneexpression.arrow_forwardExpression of recombinant proteins in yeast is an important tool for biotechnology companies that produce new drugs for human use. In an attempt to get a new gene X expressed in yeast, a researcher has integrated gene X into the yeast genome near a telomere. Will this strategy result in good expression of gene X? Why or why not? Would the outcome of this experiment differ if the experiment had been performed in a yeast line containing mutations in the H3 or H4 histone tails?arrow_forward
- LO43 Identify the levels at which gene expression can be regulated in prokaryotes and eukaryotes Gene regulation in prokaryotes can occur through the following mechanisms EXCEPT: Histone methylation O antisense RNA riboswitches repressors DNA methylation Regulatory elementsarrow_forwardWhat changes take place in chromatin structure, and what role do these changes play in eukaryotic gene regulation?arrow_forwardNorthern blotting, RT-PCR, and microarrays can be used to analyze gene expression. A lab studies yeast cells, comparing their growth in two different sugars, glucose and galactose. One student is comparing expression of the gene HMG2 under these two conditions. Which technique(s) could he use and why? Another student wants to compare expression of all the genes on chromosome 4, of which there are approximately 800. What technique(s) could she use and why?arrow_forward
- name TWO mechanisms of control of gene expression that are only used by eukaryotes and discuss why each of those mechanisms wouldn’t be possible in prokaryotes.arrow_forwardBriefly describe three ways that ATP-dependent chromatin-remodeling complexes may change chromatin structure.arrow_forwardCompare the control of gene regulation in eukaryotes and prokaryotes at the level of initiation of transcription. How do the regulatory mechanisms work? What are the similarities and differences in these two types of organisms in terms of the specific components of the regulatory mechanisms? Address how the differences or similarities relate to the biological context of the control of gene expression.arrow_forward
- Glenn Croston and his colleagues studied the relation between chromatin structure and transcription activity. In one set of experiments, they measured the level of in vitro transcription of a Drosophila gene by RNA polymerase II in the presence of DNA and various combinations of histone proteins (G. E. Croston et al. 1991. Science 251:643–649). First, they measured the level of transcription of naked DNA, with no associated histone proteins. Then they measured the level of transcription after nucleosome octamers (without H1) were added to the DNA. The addition of the octamers caused the level of transcription to drop by 50%. When both nucleosome octamers and H1 proteins were added to the DNA, transcription was greatly repressed, dropping to less than 1% of that obtained with naked DNA, as shown in the table below. GAL4-VP16 is a protein that binds to the DNA of certain eukaryotic genes. When GAL4-VP16 is added to DNA, the level of transcription by RNA polymerase II is greatly elevated.…arrow_forwardChromatin Immunoprecipitation (ChIP) experiments enable researchers to measure the levels of transcription factors, coactivators/corepressors and chromatin remodeling complexes on a specific gene in cells. In the ChIP experiment below, the recruitment of the transcription factor NfkB, Histone Deacetylase Complex (HDAC3) and p300/CBP complex to the Interleukin 12 (IL12) gene at various times (0, 30, 60 and 120 min) after treating cells with LPS are measured. Does LPS stimulate or inhibit transcription of the IL12 gene based on the recruitment of factors to the IL12 gene. Justify your answer by explaining the state of the gene before LPS and after LPS treatment (limit 5-6 sentences).arrow_forwardRegarding eukaryotic genes, it is correct to state that: a) Distal enhancer-like elements decrease the intensity of gene transcription activation b) Mutations in intronic regions of a gene can alter the levels of its corresponding protein c) They are regulated only by promoter regions, being activated or repressed by the presence of transcription factors d) The junctions of exons and introns are recognized by splicing factors, which guarantee the production of the same mRNA regardless of cell type. e) Activator and repressor proteins bind to the coding region of genes, regulating the intensity of their transcriptionarrow_forward
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