BIOCHEM-ACHIEVE(FIRST DAY DISCOUNTED)
9th Edition
ISBN: 2818000069358
Author: BERG
Publisher: MAC HIGHER
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Chapter 15, Problem 39P
Interpretation Introduction
Interpretation :
Significance of free energy change in the reaction is to be determined.
The relation between free energy change (DG) and standard free energy change (DG89) must be determined.
The relation between the equilibrium constants and the reactant and product must be determined.
Concept introduction :
A living being requires free energy input for three major processes. First is during mechanical work in cellular movements and muscular contractions. Second is during the active transport of ions and molecules across the membrane. Third is during macromolecular synthesis.
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For a Michaelis-Menten reaction, k₁=5 x 107/M-s, k-1-2 x 104/s, and k2=4 x 10²/s.
Calculate the Ks and KM for this reaction.
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The formation of maltose, a disaccharide, from two glucose molecules, is not energetically favorable. However, if this reaction is coupled with the hydrolysis of ATP, the reaction occurs more favorably.
Maltose + H2O = 2 Glucose , ΔG'o = -15.5 KJ/mol or -3.7 kcal/mol
a. Determine if the coupled reaction will occur spontaneously at standard state through calculating the Gibbs Free Energy of Reaction.
b. Calculate the equilibrium constant for each individual reaction, and for the coupled reaction (using free energy of reaction). Show that the equilibrium constant for the coupled reaction equals the equilibrium constants for the individual reactions multiplied together.
c. If the reaction medium contains the following chemical species at their given concentrations (298 K and 1.0 atm, pH = 7.0), will the reaction proceed in the forward or the reverse direction? [Maltose] = [Glucose] = 10.0 mM; [ATP] = 5.0 mM; [ADP] = [Pi] = 20 mM
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Chapter 15 Solutions
BIOCHEM-ACHIEVE(FIRST DAY DISCOUNTED)
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