CAMPBELL BIOLOGY V.2(BHCC>CUSTOM<)
18th Edition
ISBN: 9781323655573
Author: Urry
Publisher: PEARSON C
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Chapter 15.4, Problem 3CC
Summary Introduction
To determine: The activation of the gene on Philadelphia chromosome that codes for intracellular tyrosine kinase, contributing to the development of cancer.
Concept introduction:
Tyrosine kinase belongs to the group of protein kinases. It catalyzes the addition of a phosphate group from the ATP molecule generated, to a protein molecule. This addition aids in transferring a signal that induces the cell to divide.
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Describe how p53 functions to arrest cells in G1 and G2 stages of the cell cycle to regulate the progression to the S and M stages respectively
Explain the action of cyclin-dependent kinases inregulation of the cell cycle.
Part A and B
A. What below would be likely to lead to cancer development?
A) Overexpression of a cell cycle checkpoint inhibitor
B) Loss of expression of a growth factor that promotes cell cycle entry
C) Overexpression of a receptor tyrosine kinase that promotes cell cycle entry
D) Overexpression of a DNA damage repair enzyme
E) Loss of expression of a regulatory transcription factor that activates transcription of a cyclin
B. Taxols inhibit the proper function of microtubules and are frequently used as chemotherapy drugs. What is the function of microtubules during the cell cycle?
A) They promote the G1 to S checkpoint
B) They normally inhibit M phase from being completed
C) They form the mitotic spindle
E) They mediate DNA replication
F) They form the cleavage furrow during cytokinesis
Chapter 15 Solutions
CAMPBELL BIOLOGY V.2(BHCC>CUSTOM<)
Ch. 15.1 - Which one of Mendel's laws describes the...Ch. 15.1 - MAKE CONNECTIONS Review the description of...Ch. 15.1 - WHAT IF? Propose a possible reason that the first...Ch. 15.2 - A white-eyed female Drosophila is mated with a...Ch. 15.2 - Neither Tim nor Rhoda has Duchenne muscular...Ch. 15.2 - MAKE CONNECTIONS Consider what you learned about...Ch. 15.3 - When two genes are located on the same chromosome,...Ch. 15.3 - VISUAL SKILLS For each type of offspring of the...Ch. 15.3 - Prob. 3CCCh. 15.4 - Prob. 1CC
Ch. 15.4 - Prob. 2CCCh. 15.4 - Prob. 3CCCh. 15.5 - Gene dosagethe number of copies of a gene that are...Ch. 15.5 - Reciprocal crosses between two primrose varieties,...Ch. 15.5 - WHAT IF? Mitochondrial genes are critical to the...Ch. 15 - What characteristic of the sex chromosomes allowed...Ch. 15 - Why are males affected by X-Iinked disorders much...Ch. 15 - Why are specific alleles of two distant genes more...Ch. 15 - Prob. 15.4CRCh. 15 - Explain how genomic imprinting and inheritance of...Ch. 15 - A man with hemophilia (a recessive, sex-linked...Ch. 15 - Pseudohypertrophic muscular dystrophy is an...Ch. 15 - A wild-type fruit fly (heterozygous for gray body...Ch. 15 - A planet is inhabited by creatures that reproduce...Ch. 15 - Using the information from problem 4, scientists...Ch. 15 - A wild-type fruit fly (heterozygous for gray body...Ch. 15 - Assume that genes, A and B are on the same...Ch. 15 - Two genes of a flower, one Controlling blue (B)...Ch. 15 - You design Drosophila crosses to provide...Ch. 15 - Banana plants, which are triploid, are seedless...Ch. 15 - EVOLUTION CONNECTION Crossing over is thought to...Ch. 15 - SCIENTIFIC INQUIRY DRAW IT Assume you are mapping...Ch. 15 - WRITE ABOUT A THEME: INFORMATION The continuity of...Ch. 15 - SYNTHESIZE YOUR KNOWLEDGE Butter flies have an X-Y...
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- 1. (a) Describe the generalized model of the cell cycle. Demonstrate how cyclins and cyclin-dependent kinases can regulate the cell cycle. (b). Describe three ways in which cells lose their ability to regulate their growth to become cancerous.arrow_forwardDiscuss about Surveillance Mechanisms in Cell Cycle Regulationarrow_forwardDescribe what happens to the G1 cell cycle check point of a skin cell that is stimulated to divide by neighboring cells following an injury. Describe the pathway from the growth factor signal to the cell cycle checkpoint regulation of gene expression resulting in cell duplication. Briefly explaining the mechanismarrow_forward
- Hi, can you explain this concept: cell cycle progression can be halted at several points by the tumor suppressor gene product p53, activated in response to checkpoints sensing DNA and possibly also chromosome damage; loss of p53 would remove this brake to cycling. How these events can lead to cancer progression?arrow_forwardExplain the significance of the G1, G2, and M checkpoints and thego-ahead signals involved in the cell cycle control system.arrow_forwardDescribe how the tumor-suppressor genes Rb, p53 and p21 regulate the cell cycle.arrow_forward
- Q. Cyclins and CDK(inase) complexes regulate the cell cycle. Which of the following statements is true? A. Cyclins activate CDKs which remove phosphates from other proteins. B. Cyclins activate CDKs which add phosphates to other proteins. C. CDKs activate cyclins which remove phosphates from other proteins. D. CDKs activate cyclins which add phosphates to other proteins.arrow_forwardIn your own words, explain how cancer cells differ from normal cells in regard to the following: Molecular controls of the cell cycle (include Cdk and Cdk/cyclin complexes, p53 gene/protein, Rb gene/protein in response)arrow_forwarda. Describe the importance of Wee1, Myt1, CAK and cdc25 activity on the activation of the cyclin B/CDK1 complex. b. Explain the effect of DNA damage on activation of the cyclin B/CDK1 complex and cell cycle progression.arrow_forward
- A Patients with an inherited cancer have a mutation in a zinc-finger motif of P21 (a cell-cycle regulatory gene). Which of the following is the most likely result of this A) Decreased binding of a transcription factor to a DNA sequence B) Enhanced binding of hormones to receptors C) Enhanced transport of a hormone receptor complex into the nucleus D) Stimulation of mRNA synthesis E) "Unzipping" of leucine-rich helicesarrow_forwardHow does MPF trigger M phase of the cell cycle? A. MPF phosphorylates proteins that triggers the activation of M phase B. MPF has a regulatory role in breakdown of the nuclear envelope during M phase C. MPF is a dimer subunit that is turned on during S phase to aid with chromosome replication D. MPF Cdk subunits regulate M phasearrow_forwardReview Figure 12.16 on cell cycle control. Would you expect MPF (maturation-promoting factor) activity to remain steady during cleavage? Explain.arrow_forward
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