Essentials Of Genetics (9th Global Edition)
9th Edition
ISBN: 9780134143637
Author: William S. Klug, Michael R. Cummings
Publisher: Pearson Global Edition
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Chapter 16, Problem 11PDQ
Part of the Ras protein is associated with the plasma membrane, and part extends into the cytoplasm. How does the Ras protein transmit a signal from outside the cell into the cytoplasm? What happens in cases where the ras gene is mutated?
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Students have asked these similar questions
what are the rolls that the p53 gene and RAS protein take on when trying to stop a cancer cell from further replicating. Also, what would happen if a mutation were to occur in both genes?
What are Ras protein and p53? How can mutations in the genes for these proteins contribute to cancer?
Which of the following defects in RAS would be tumorigenic? multiple answers
A.
Deletion of nucleotide binding domain
B.
Inactivation of Guanine Exchange Factor (GEF)
C.
Mutation at amino acid 61 that prevents hydrolysis of bound GTP
D.
Inactivation of GTPase Protein (GAPS)
E.
Mutation that prevents binding of GTP
Chapter 16 Solutions
Essentials Of Genetics (9th Global Edition)
Ch. 16 -
CASE STUDY | I thought it was safe
A middle-aged...Ch. 16 -
CASE STUDY | I thought it was safe
A middle-aged...Ch. 16 -
CASE STUDY | I thought it was safe
A middle-aged...Ch. 16 - HOW DO WE KNOW? In this chapter, we focused on...Ch. 16 -
2. Review the Chapter Concepts list on page 307....Ch. 16 - What is the relationship between signal...Ch. 16 - Where are the major regulatory points in the cell...Ch. 16 -
5. Describe kinases and cyclins. How do they...Ch. 16 - (a) How does pRB function to keep cells at the G1...Ch. 16 - What is the difference between saying that cancer...
Ch. 16 -
8. What is apoptosis, and under what...Ch. 16 - Define tumor-suppressor genes. Why is a mutation...Ch. 16 - A genetic variant of the retinoblastoma protein,...Ch. 16 -
11. Part of the Ras protein is associated with...Ch. 16 - If a cell suffers damage to its DNA while in S...Ch. 16 - Prob. 13PDQCh. 16 - Prob. 14PDQCh. 16 - Prob. 15PDQCh. 16 - Prob. 16PDQCh. 16 - Prob. 17PDQCh. 16 - How do normal cells protect themselves from...Ch. 16 - Prob. 19PDQCh. 16 - Explain how environmental agents such as chemicals...Ch. 16 - Radiotherapy (treatment with ionizing radiation)...Ch. 16 - Genetic tests that detect mutations in the BRCA1...Ch. 16 - Prob. 23PDQCh. 16 - Prob. 24PDQCh. 16 - Prob. 25PDQCh. 16 - Prob. 26PDQCh. 16 - Prob. 27PDQCh. 16 - Prob. 28PDQ
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- Describe the common signal transduction event that is perturbed by cancer-promoting mutations in the genes encoding RAS and NF-1. Why are mutations in RAS more commonly found in cancers than mutations in NF-1?arrow_forwardA mutation in the Ras protein renders Ras constitutively active (RasD). What is constitutive activation?arrow_forwardDo you think there are more unique alleles of p53 that lead to cancer or more unique alleles of Ras that lead to cancer? Please explain.arrow_forward
- What are ras Proto-oncogenes ?arrow_forwardWe have studied Ras signal transduction pathway. In an experiment, two different mutations were produced using different chemicals. The proteins with mutation are listed below. State what will be the effect of each mutation and explain whether it will result in cell proliferation or not. GEF protein GTPasearrow_forwardWhich of the following mutations would produce a form of the Ras protein that would be more difficult to inactivate than normal Ras? Briefly explain your reasoning.(i) A mutation that allows Ras to cleave (hydrolyze) GTP more rapidly than usual(ii) A mutation that causes Ras to bind Ras-GAP more tightly than usual(iii) A mutation that causes Ras to cleave (hydrolyze) GTP more slowly than usualarrow_forward
- How is the signal generated by binding of TGF-β to cell-surface receptors transmitted to the nucleus, where changes in target-gene expression occur?arrow_forwardHow does each of these small GTP-binding proteins contribute to the regulation of cell migration?arrow_forwardMutations that inactivate p53 have a recessive phenotype, whereas mutations affecting Ras are dominant. Explain the difference.arrow_forward
- In a normal cell, micro-RNA (mIR-433) acts to regulate ras - what would happen to a cell if there was a mutant (non-functioning) form of mIR-433 acting on ras?arrow_forwardWhat is the function of RAG1? What will happen if RAG1's function is lost due to mutations?arrow_forwardIs the presence of oncogenic Ras necessary for transient inflammatory stimulation to induce chronic pathologies (such as cancer) OR is chronic inflammation essential for oncogenic Ras to induce tumorigenesis?arrow_forward
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