Biological Science (6th Edition)
6th Edition
ISBN: 9780321976499
Author: Scott Freeman, Kim Quillin, Lizabeth Allison, Michael Black, Emily Taylor, Greg Podgorski, Jeff Carmichael
Publisher: PEARSON
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Chapter 16, Problem 12PIAT
Summary Introduction
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Interpret the results and determine the reason for zebrafish allele expressing different
Introduction:
Transcription is a process where the DNA (deoxyribonucleic acid) template is used in order to create an RNA (ribonucleic acid) molecule comprising of a complementary sequence to the DNA. Following to transcription, mRNA (messenger RNA) is used in order to synthesize proteins via translation process.
The study examined the expression of transporter mRNA and protein produced in zebrafish homozygous for each of the alleles and found the following results: The mRNA and protein expressed in dark color zebrafish allele and no mRNA and protein expressed in light color zebrafish allele.
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Could quantitative PCR, which uses a DNA-binding dye, to show how many copies of the target DNA sequence could be used to quantify the amount of mRNA in a cell? Would you expect that a metabolically active tissue such as the liver would show more cDNA copies in such a method, compared to less metabolically active tissues such as skin cells?
One reason that the types and amounts of mRNAs are quantified in different tissue types is to compare which genes are activated and which are inactive. It used to be thought that any gene that was transcribed was automatically translated. The discovery of RNA-degrading systems shows that the real situation in cells is more complemented. Do you believe that a larger amount of mRNA of a given type, say for alpha hemoglobin in…
Your friend has discovered that the same human promoter is responsible for producing two different proteins. In Kidney cells it is responsible for the production of protein A while in Brain cells it is responsible for the production of Protein B. Your friend has concluded that this promoter must be controlling two different genes. Do you agree or disagree with your friend's conclusion? Explain why or why not. Be sure to describe the molecular events to support your answer.
A genon wide analyst of human genome indicated that approximately 1500 genes encoded transcription factors that are important for sequence specific gene expression. based on this information approximately what percentage of the protein coding genes in human belong to the transcription factors?
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Chapter 16 Solutions
Biological Science (6th Edition)
Ch. 16 - Prob. 1TYKCh. 16 - 2. Which of the following is an important...Ch. 16 - Prob. 3TYKCh. 16 - Prob. 4TYKCh. 16 - Prob. 5TYUCh. 16 - A minimal genetic code requires only 21 codons–one...Ch. 16 - Prob. 7TYUCh. 16 - Prob. 8TYUCh. 16 - MODEL Draw a hypothetical metabolic pathway in...Ch. 16 - Prob. 10TYPSS
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- A GWAS study using genomic resequencing may find a statistically significant SNP that is: (choose all that apply) Group of answer choices near a regulatory sequence that causes a change in a gene's expression resulting in the phenotype studied. in a gene's exon that changes that gene's product and produces the phenotype studied. near a gene that causes the phenotype studied. in a regulatory sequence that changes the expression of a gene resulting in the phenotype studied.arrow_forwardRsearcher has discovered that one human promoter is responsible for producing two different proteins (Protein K and Protein B) from the same gene. In Kidney cells it is responsible for the production of Protein K, while in Brain cells it is responsible for the production of Protein B. How are these different proteins being produced from the same gene? Describe the mechanismarrow_forwardSuppose you had funding to do a genome-wide gene expression experiment (20,000 genes). You can use a total of 20 RNA samples. Briefly describe the experiment you would run. In the context of your experiment, what is a false positive? In the context of your experiment, what is a false negativearrow_forward
- Many aspects of gene function can be nicely explained with the one-gene-one-enzyme hypothesis, which states that a gene controls the production of an enzyme. Which of the following findings about gene expression, though, requires an expansion of this simple concept? Choose an answer below: Non-enzyme proteins are made from genes too. Some genes code for RNA molecules only. Enzymes composed of different polypeptides are coded for by more than one gene. a and c, but not b a, b, and carrow_forwardA researchist has found that 1 human promoter is responsible for producing 2various proteins (Protein K & Protein B) from the same gene. In Kidney cells it is responsible for the production of Protein K, while in Brain cells it is responsible for the production of Protein B. How are these different proteins being produced from the same gene? Please describe the mechanism to support the answer.arrow_forwardThe sequencing of entire genomes has made it possible to examine the level of gene expression in a particular cell or tissue by using oligonucleotide probes to assess the mRNA expression level from a particular gene. This is done most effectively through the use of what experimental technique?arrow_forward
- Comparisons between human and chimpanzee genomes indicate that a gene that may function as a wild-type or normal gene in one primate may function as a disease-causing gene in another [The Chimpanzee Sequencing and Analysis Consortium (2005). Nature 437:69–87]. For instance, the PPARG locus (regulator of adipocyte differentiation) is a wild-type allele in chimps but is clearly associated with Type 2 diabetes in humans. What factors might cause this apparent contradiction? Would you consider such apparent contradictions to be rare or common? What impact might such findings have on the use of comparative genomics to identify and design therapies for disease-causing genes in humans?arrow_forwardCould quantitative PCR, which uses a DNA-binding dye, to show how many copies of the target DNA sequence could be used to quantify the amount of mRNA in a cell? Would you expect that a metabolically active tissue such as the liver would show more cDNA copies in such a method, compared to less metabolically active tissues such as skin cells? One reason that the types and amounts of mRNAs are quantified in different tissue types is to compare which genes are activated and which are inactive. It used to be thought that any gene that was transcribed was automatically translated. The discovery of RNA-degrading systems shows that the real situation in cells is more complemented. Do you believe that a larger amount of mRNA of a given type, say for alpha hemoglobin in immature red blood cells is a reliable indicator that more alpha hemoglobin protein will be made in those cells?arrow_forwardYou are studying a mutation in mice, which acts dominantly. Mice that have only one copy of the allele carrying this mutation have a kinky tail phenotype. You identify the gene that the mutation affects and find that the codon that encodes the second amino acid in the predicted protein has been mutated to a stop codon. Would you characterize this mutation as a loss-of-function or a gain-of-function and what specific subtype (hypermorphic, antimorphic, etc. ) within these categories? Explain your reasoning.”arrow_forward
- Debes et al recently described how aging in humans, mice, nematodes, and other eukaryotes is associated with an increase in the average speed of transcriptional elongation by RNA polymerase II. Overexpression of some proteins that decreased PolII elongation speed extended lifespan in the fly Drosophila. For each of the following proteins, predict whether overexpression of that protein (assuming all other cellular components are normal) would likely reduce transcriptional speed, and briefly justify your answer. a) Mediator proteinsb) Histone proteinsc) Insulator binding proteinsarrow_forwardPlease answer both questions Explain five ways that eukaryotic gene regulation is more complex than bacterial gene regulation? Mutations in the promoter region of the B-globin gene indicate that some areas are more sensitive than others. When mutations occur in consensus sequences(modular elements such as GC box, CAAT box, and TATA box), does transcription usually increase or decrease? Explain.arrow_forwardIn a first attempt to describe the relationship between genes and phenotypes, Beadle and Tatum in the 1940s stated that each gene is a section of the genome that codes for a specific enzyme (one-gene-one-enzyme hypothesis). Which more recent discoveries regarding gene expression are not covered by this hypothesis? Some genes are transcribed into functional RNA molecules that are not translated into protein. Genes code for proteins other than enzymes. Enzymes comprised of several different polypeptides, such as RNA polymerase, are encoded by more than one gene. a and b, but not c a, b, and carrow_forward
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