Biological Science (6th Edition)
6th Edition
ISBN: 9780321976499
Author: Scott Freeman, Kim Quillin, Lizabeth Allison, Michael Black, Emily Taylor, Greg Podgorski, Jeff Carmichael
Publisher: PEARSON
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Chapter 16, Problem 13PIAT
A small portion of the human transport protein amino acid sequence is shown below. The upper sequence is associated with darker skin, and the lower sequence is associated with lighter skin. What DNA base-pair change created the light-skin form of the human protein from the gene that coded for the dark-skin form?
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Students have asked these similar questions
A small section of bacterial DNA template (anti-sense) strand has the following nucleotide sequence:
GTT GTG ACG TAA
A mutation in the above sequence involved a substitution of a single base, but did not affect the protein produced when the gene involved was transcribed and translated.
Which of the following gene sequences could have the mutation described above?
a.
GTT GTG ACA TAA
b.
GTT GGG ACG TAA
c.
GTA GTG ACG TAA
d.
GTT GTG ACT TAA
Human wildtype and mutant alleles are identical in sequence except for a single base-pair substitution that changes one nucleotide towards the end of intron 2. The wildtype and mutant sequences of the affected portion of the mRNA are listed in the following table.
Explain how a single base substitution could alter the reading frame, which could result in a physiological disorder?
Mobile genetic elements, such as the Alu sequences, are found in many copies in human DNA. In what ways could the presence of an Alu sequence affect a nearby gene?
Chapter 16 Solutions
Biological Science (6th Edition)
Ch. 16 - Prob. 1TYKCh. 16 - 2. Which of the following is an important...Ch. 16 - Prob. 3TYKCh. 16 - Prob. 4TYKCh. 16 - Prob. 5TYUCh. 16 - A minimal genetic code requires only 21 codons–one...Ch. 16 - Prob. 7TYUCh. 16 - Prob. 8TYUCh. 16 - MODEL Draw a hypothetical metabolic pathway in...Ch. 16 - Prob. 10TYPSS
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- What percentage of the DNA in the genome actually corresponds to genes? How much is actually protein-coding exons? What makes up the rest?arrow_forwardConsider a single base insertion mutation between the 3rd and 4th codons in a natural gene that encodes a protein 100 amino acids long. Is it more likely that the protein produced by this mutant allele will be shorter or longer than 100 amino acids long?arrow_forwardin the human gene for the beta chain of hemoglobin, the first 30 nucleotides in the amino acid coding region is represented by the sequence 3'TACCACGTGGACTGAGGACTCCTCTTCAGA-5'. What is the sequence of the partner strand? If the DNA duplex for the beta chain of hemoglobin above were transcribed from left to right, deduce the base sequence of the RNA in this coding region.arrow_forward
- Refer to the DNA sequence provided:3’ -TACTGAAGCGGCAGCCCCGCATGAGTAGACCTTACT-5’a. What is the mRNA transcript of the anticoding strand of the DNA model?arrow_forwardWhich of the following mutations in the protein-coding region of a gene is more likely to lead to complete loss of function of the encoded protein: an insertion of six nucleotides or a deletion of two nucleotides? Briefly explain your answer.arrow_forwardA small section of bacterial DNA template (antisense) strand has the following nucleotide sequence: CGA AAA GAG AAT A mutation in the above sequence involved a substitution of a single base, resulting in an incomplete protein due to a nonsense mutation. Which of the following gen sequences exemplifies the mutation described above? a. CGA UAA GAG AAT b. CGA AAA AAG AAT c. CGA AAA GAG ACT d. UGA AAA GAG AATarrow_forward
- Could a single nucleotide deletion restore the function of a protein-coding gene interrupted by the insertion of a 4-nt sequence? Explain.arrow_forwardA small section of bacterial DNA template (anti-sense) strand has the following nucleotide sequence: AAG TAT TAT GCA A mutation in the above sequence involved the insertion of a single base, leading to a shift in the reading frame of the gene, resulting in altered amino acids downstream from the insertion. Which of the following gene sequences exemplifies the mutation described above? a. AAG CTA TTA TGC A b. AG TAT TAT GCA c. AAG TATU TAT GCA d. AAG TAT TAGT GCAarrow_forwardWhich of the following mutations would have the greatest negative impact on the protein product of a gene? A. a single base deletion close to the end of the coding region of a gene. B. a single base insertion near the start of the coding region of the gene C. a base-pair substitution D. a deletion of three bases near the middle of the genearrow_forward
- Some S. aureus strains can produce an enzyme called beta-lactamase, which breaks down beta-lactam drugs like methicillin. These strains that make beta-lactamase have a gene called mecA. Draw a diagram of the bacterial DNA encoding this gene, including the following terms: promoter, terminator, coding region.arrow_forwardA small section of bacterial DNA template (anti-sense) strand has the following nucleotide sequence: GTT GTC CAC TCGA mutation in the above sequence involved the deletion of a single base, leading to a shift in the reading frame of the gene, resulting in an incomplete protein. Which of the following gene sequences exemplifies the mutation described above? Select one: a. TT GTC CAC TCG b. GTT GAT CCA CT c. GT ATC CAC TCG d. ATT GTC AC TCGarrow_forwardOn the basis of current knowledge, the protein-encoding regions account for only about 3% of the human genome. What is the function of the rest of the DNA?arrow_forward
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