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Interpretation:
To give the explanation whether the acid-catalyzed hydrolysis of acetamide is a reversible or irreversible reaction.
Concept introduction:
In acid hydrolysis of amide, acid protonates carbonyl oxygen of amide which increases the electrophilicity of the carbonyl carbon. Water acts as a nucleophile gets attached to the carbonyl carbon of amide to form tetrahedral intermediate(A) which on losing proton get converted to tetrahedral intermediate(B). The nitrogen of tetrahedral intermediate (B) gets protonated to form tetrahedral intermediate(C). The
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Chapter 16 Solutions
Organic Chemistry; Modified MasteringChemistry with Pearson eText -- ValuePack Access Card; Study Guide and Student Solutions Manual for Organic Chemistry, Books a la Carte Edition (7th Edition)
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- Click the "draw structure" button to activate the drawing utility. Some penicillins cannot be administered orally because their B-lactam is rapidly hydrolyzed by the acidic environment of the stomach. Draw the product that forms in the following hydrolysis reaction. H H R. H3O+ -N- но HINarrow_forwardBisphenol A is widely used as a building block in polymer synthesis and is found in the polycarbonate hard plastics of reusable drink containers, DVDs, cell phones, and other consumer goods. Bisphenol A is reported to have estrogenic activity, and its widespread occurrence in our environment is a potential concern. Describe one or two biochemical experiments that could be done to compare the activity of bisphenol A with that of its estradiol, its structural relative.arrow_forwardDescribe the Concept of Acid-Catalyzed Ester Hydrolysis and Transesterification.arrow_forward
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