Campbell Biology in Focus (2nd Edition)
2nd Edition
ISBN: 9780321962751
Author: Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Jane B. Reece
Publisher: PEARSON
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Chapter 16.3, Problem 1CC
Summary Introduction
To discuss:
How mutation in protein coding genes functioning in apoptosis can lead to cancer.
Introduction:
Apoptosis is defined as the programmed cell death (PCD). It is a process, which only occurs in multi-cellular organisms. The cells undergoing PCD include blebbing, fragmentation of DNA (deoxyribonucleic acid), cell shrinkage, and engulfment by the phagocytes.
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Chapter 16 Solutions
Campbell Biology in Focus (2nd Edition)
Ch. 16.1 - Prob. 1CCCh. 16.1 - MAKE CONNECTIONS Explain how the signaling...Ch. 16.1 - How do fruit fly maternal effect genes determine...Ch. 16.2 - Deitys egg donor and surrogate mother were...Ch. 16.2 - WHAT IF? If you were a doctor who wanted to use...Ch. 16.3 - Prob. 1CCCh. 16.3 - Prob. 2CCCh. 16.3 - Prob. 3CCCh. 16 - Muscle cells differ from nerve cells mainly...Ch. 16 - Cell differentiation always involves A. the...
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- Another model, the random model, proposes that any cell in a malignant tumor has the potential to form a new tumor. Does the cancer stem cell hypothesis contradict this idea?arrow_forwardExplain the difference between a proto-oncogene and a tumor suppressor gene.arrow_forwardDescribe the steps by which the TP53 gene responds to DNA damage and/or cellular stress to promote cell-cycle arrest and apoptosis. Given that TP53 is a recessive gene and is not located on the X chromosome, why would people who inherit just one mutant copy of a recessive tumor-suppressor gene be at higher risk of developing cancer than those without the recessive gene?arrow_forward
- Describe the effects of the mutation causing the p21 promoter to no longer bind p53 on cell signaling pathways and metabolism or cell cycle control.arrow_forwardMutations in p53 are commonly associated with malignant tumor formation. Do deleterious mutations in p53 usually lead to a loss of function or gain of function of the protein?arrow_forwardCan we cure cancer by restoring the function of tumor suppressor proteins such as mutant p53 or pRb? If so, how is this possible?arrow_forward
- Explain about the TP53 Tumor-suppressor Gene ?arrow_forwardExplain in detail two different genetic mutations that can promote the development of cancer. Include the name (or type) of gene mutated and whether the expression of the gene is upregulated or downregulated. Provide a description of the role the gene plays in regulating the cell cycle and how the cell is affected when the gene no longer produces a functional proteinarrow_forwardHow tumor-suppressor mutations contribute to cancer?arrow_forward
- A protein called p53 promotes the expression of genes encoding DNA repair enzymes. Badly damaged DNA prompts p53 to trigger apoptosis, and the cell dies. Why might mutations in the gene encoding p53 be associated with a high risk for cancer?arrow_forwardExplain how mutations in tumor-suppressor genes can be recessive at the level of the cell but cause dominantly inherited predispositions to cancer.arrow_forwardExplain the role of p53 protein in protecting normal cells against cancer. With respect to this protein and its function, explain how a normal cell turns cancerous.arrow_forward
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