Introduction:
Hydrophilic hormone receptors are located on the plasma membrane. They are peptide hormones (insulin) and soluble in water. They cannot diffuse through the plasma membrane, and their receptors are present on the cell surface (transmembrane protein receptor). Hormone binding on receptors leads to cell signal transduction, and they act through secondary messengers.
Hydrophobic hormone receptors are located in the cytoplasm or nucleus. They are steroid hormones (testosterone and thyroid hormone) and soluble in lipid. Hence, they can diffuse through the phospholipids of the plasma membrane.
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Chapter 17 Solutions
LSC (CONCORDIA UNIV ST PAUL) BIO 315/316: B&N DPF Connect with APR and Phils Online Access for Anatomy and Physiology: The Unity of Form and Function 180 Day Access ENTRP
- Compare and contrast intracellular and cell membrane bound hormone receptors.arrow_forwardIs a hormone altered as a consequence of its interaction with a receptor? Is the receptor altered as a consequence of hormone binding? What are the forces that bind hormone and receptor?arrow_forwardWhich class of hormones consists entirely of lipid-soluble hormones? Name the only hormone in the other chemical class that is lipid soluble.arrow_forward
- What are “antagonistic” hormones? Provide an example.arrow_forwardWhat general features make a chemical compound a hormone, and how do hormones achieve specificity for certain kinds of target cell?arrow_forwardWhy is the fact that a monomeric hormone binds simultaneously to two identical receptor molecules, thus promoting the formation of a dimer of the receptor, considered remarkable?arrow_forward
- Why do peptide and steroid hormones bind different kinds of receptor, and how does this difference affect the resulting signaling pathways in the target cell?arrow_forwardList the major categories of hormones on the basis of their chemical structure. Describe how hormones interact with tissues to produce a response. Describe three methods of regulating the release of hormones.arrow_forward1) Why are steroid hormones unable to be stored in secretory vesicles? 2) Other than increasing hormone solubility, describe two other consequences of hormones binding to binding proteins.arrow_forward
- Trace in a stepwise manner the signaling pathway that involves a g-protein receptor leading to the release of intracellular calcium. Specify what class of hormones would be involved in this pathway.arrow_forwardHow do receptors impart specificity within the endocrine system? What might be some advantages of having complex mechanisms for hormone action (such as second messengers)?arrow_forwardDoes the following table properly summarize negative feedback loop of each tropic hormone? If not, place the correct answer beside each box.arrow_forward
- Human Physiology: From Cells to Systems (MindTap ...BiologyISBN:9781285866932Author:Lauralee SherwoodPublisher:Cengage Learning
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