To discuss:
Synthesis and effect of the cyclooxygenase products such as prostacyclin, thromboxanes, and prostaglandins.
Introduction:
The eicosanoids are the family of paracrine secretions. They contain 20 carbon backbones, which are derived from the arachidonic acid (polyunsaturated fatty acid). Peptide hormones and some stimuli release the arachidonic acid from the phospholipid present in the plasma membrane. Finally, lipoxygenase and cyclooxygenase enzymes convert the arachidonic acid to various eicosanoids such as leukotrienes, prostacyclin, thromboxane, and prostaglandins (PGs).
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