BIOCHEMISTRY 2 TERM ACCESS
BIOCHEMISTRY 2 TERM ACCESS
9th Edition
ISBN: 9781319402877
Author: BERG
Publisher: MAC HIGHER
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Chapter 18, Problem 53P
Interpretation Introduction

1) Label subpart

Interpretation:

The reason for high serum levels of lactate, alanine, and succinate when there is a lack of ATP-ADP translocase.

Concept introduction:

ADP-ATP translocase is also termed as the adenine nucleotide translocase. This carrier protein helps in the translocation of mitochondrial ATP and cytosolic ADP across the inner mitochondrial membrane. ATP is produced by the electron-transport chain occurring in the inner mitochondrial membrane.

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The Cori Cycle. Before vigorous exercise (at rest) the level of blood lactate is at its normal level (about 25 mM). During a 400 m sprint, the value rises sharply in less than a few minutes to about 200 mM and then declines slowly to around 40 mM over 60 mins after the sprint. a. Discuss (or illustrate) the pathway and reactions that cause the rapid increase in lactate concentration during the sprint.  b. What causes the slow decline in lactate concentration after the sprint? Why does the decrease occur more slowly than the rapid increase?  c. What enzymatic reaction is responsible for maintaining the lactate concentration above zero at recovery after the sprint?
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