(a)
Interpretation:
The one equivalent of the malonic ester reacted with one equivalent of
Concept introduction:
In first case, base initiates the reaction by abstraction of a proton from the malonic ester. Enolate anion is formed which attacks
In second case, base initiates the reaction by abstraction of a proton from the malonic ester. Enolate anion is formed which attacks
(b)
Interpretation:
The one equivalent of the malonic ester reacted with one equivalent of
Concept introduction:
In first case, base initiates the reaction by abstraction of a proton from the malonic ester. Enolate anion is formed which attacks
In second case, base initiates the reaction by abstraction of a proton from the malonic ester. Enolate anion is formed which attacks
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Chapter 18 Solutions
Organic Chemistry (Looseleaf) - With Access
- Use the malonic ester synthesis to prepare each carboxylic acid.arrow_forwardWhat is the best combination to create a beta-dicarbonyl (1,3-dicarbonyl) compound? a) enolate + aldehyde b) enolate + acid derivative c) enolate + alpha-halogenated carbonyl d) enolate + conjugated carbonyl (Michael addition)arrow_forwardCan you help find the best reagent for this problem?arrow_forward
- Draw the enol form of each keto tautomer in parts (a) and (b), and the keto form of each enol tautomer in parts (c) and (d).arrow_forwardChoose the best reagents to complete the following reactions.arrow_forwardWhy can you not use this reaction to make a secondary amine? a) Alkyl halides are weak electrophiles.b) Primary amines are weak nucleophiles.c) The primary amine is too nucleophilic, so over-reaction will occur.d) The secondary amine product is more nucleophilic than the primary amine reactant, so over-reaction will occur.arrow_forward
- Organic Chemistry: A Guided InquiryChemistryISBN:9780618974122Author:Andrei StraumanisPublisher:Cengage Learning