Concept explainers
To discuss:
Determinants of blood type, the different ABO blood types, and the differences in genetics and RBC antigens.
Introduction:
Blood transfusion incompatibility can be fatal, and therefore necessitates knowledge of both donor and recipient blood types. The antibodies are proteins secreted by the plasma cells and which circulate in the plasma, and the antigens are proteins, glycolipids, or glycoproteins that are expressed, in the case of ABO blood types, on the surface of RBCs. Antibodies, by binding to antigens, label the antigens for destruction as part of the body’s immune response.
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