WTCC BIOLOGY PACKAGE W/ ACCESS >C<
WTCC BIOLOGY PACKAGE W/ ACCESS >C<
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ISBN: 9781269715485
Author: Urry
Publisher: Pearson Custom Publishing
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Chapter 19, Problem 10TYU
Summary Introduction

To explain: How neuraminidase inhibitor drug Oseltamivir (Tamiflu) helps in prevention of flu or reduces disease course of flu in a flu patient.

Introduction: An antiviral drug, Oseltamivir (Tamiflu), is recommended for patients infected by the influenza virus. Influenza virus is an RNA virus belonging to the family of Orthomyxoviridae. This virus produces flu with symptoms such as fever, sore throat, and coughing. Oseltamivir is a drug that inhibits the enzyme neuraminidase.

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You think you need may have found a new inhibitor (NI) of the HIV protease, so you performed few experiments to characterize its behavior. You found that if you add an excess of substrate to the protease in the presence of the inhibitor, enzyme activity decreased at low substrate but reached the same vmax as observed in the absence of the inhibitor. Also, the affinity of the substrate for the enzyme is decreased by the inhibitor. What class of inhibitor is NI, competitive, uncompetitive, non competitive, or mixed type?
In the Avery experiment, mice were killed if they injected with S strain cells. Furthermore, incubation with extract from dead S strain cells could transform non pathogenic cells into pathogenic cells. This effect of S strain extract was eliminated if S strain extract is treated with what enzyme before incubation with non-pathogenic cells? protease DNAse RNAse Lipase
AZT (zidovudine) inhibits the synthesis of the HIV virus RNA because AZT resembles substrate molecules. Which kind of inhibition is most likely taking place in this reaction?
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