The different experimental conditions used to give the major and minor product distribution should be given. Concept Introduction: Carbonyl compound when treated with LDA (Lithium Diisopropylamide) undergoes deprotonation at the α -carbon to form enolate. The enolate formed is resonance stabilized as the negative charge will be spread over other atoms too. The resonance stabilized intermediate undergoes reaction with other molecule of carbonyl (same or different) to form the respective products. If LDA is used as a base the less substituted α carbon is deprotonated due to steric hindrance. Deprotonation of α carbon to form enolate Nucleophilic attack of enolate S N 2 reaction with alkyl halide Racemic mixture: A racemic mixture is simply a mixture containing an equal amount of each enantiomer. Asymmetric center is a sterocenters which arises to hydrocarbons if the carbon is bonded to four different groups. Chiral carbon: Chiral carbon is the one which is bonded to four different molecules or groups.

Question

Carbocations undergo 1,2-methyl shift or 1,2-hydride shift to produce a more stable intermediate. Give the major product(s) obtained from the reaction of the alkene with HBr.SHOW THE FORMATION OF THE CARBOCATION, THE SHIFT THAT MAY OCCUR, AND THE MAJOR PRODUCT FORMED.

Answer 1

Question

Chapter 19, Problem 19.51P

Interpretation Introduction

Interpretation:

The different experimental conditions used to give the major and minor product distribution should be given.

Concept Introduction:

Carbonyl compound when treated with LDA (Lithium Diisopropylamide) undergoes deprotonation at the α-carbon to form enolate. The enolate formed is resonance stabilized as the negative charge will be spread over other atoms too. The resonance stabilized intermediate undergoes reaction with other molecule of carbonyl (same or different) to form the respective products. If LDA is used as a base the less substituted α carbon is deprotonated due to steric hindrance.

Deprotonation of α carbon to form enolate

Nucleophilic attack of enolate

S_N2 reaction with alkyl halide

Racemic mixture: A racemic mixture is simply a mixture containing an equal amount of each enantiomer.

Asymmetric center is a sterocenters which arises to hydrocarbons if the carbon is bonded to four different groups.

Chiral carbon: Chiral carbon is the one which is bonded to four different molecules or groups.

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