Concept explainers
What type of cells would develop if you injected embryos with a reagent that blocked the FGF receptor, thus preventing its signaling? What about with a reagent that turned on the FGF receptor, thereby causing it to be always on?
To determine: The cells that would develop even after blocking FGF receptor and the effect on persistently active FGF receptor.
Introduction: Colony-stimulating factors (CSF) are the molecules that are a combination of polysaccharide and protein; thus, called glycoproteins. These are the factors that help in stimulating the production, proliferation and differentiation of various types of blood cells in the body.
Explanation of Solution
The different cells of the body undergo diverse cell fate due to molecule signalling and decision-making. The FGF (fibroblast growth factor) receptor is important protein receptor that regulates the growth of fibroblasts. The cells that will keep on dividing and differentiating after adding a reagent that blocks FGF receptor are the muscle precursor cells and nerve cord precursor cells. This is because the muscle precursor cells and nerve cord precursor cells do not have FGF receptor, and therefore its blocking willnot affect its functioning. On adding a reagent that persistently activates FGF receptor or over activates it can result in the various pathological conditions like unregulated cell growth, tumour genesis, and skeletal abnormalities like achondroplasia and craniosynostosis.
Want to see more full solutions like this?
Chapter 19 Solutions
EP CONNECT ONLINE ACCESS FOR BIOLOGY
- A scientist observes a mutation in the transmembrane region of EGFR that eliminates its ability to be stabilized by binding interactions during dimerization after ligand binding. Which hypothesis regarding the effect of this mutation on EGF signaling is most likely to be correct? EGF signaling cascades would be active for longer in the cell. EGF signaling cascades would be active for a shorter period of time in the cell. EGF signaling cascades would not occur. EGF signaling would be unaffected.arrow_forwardWhich of the following modifications of the Epithelial Growth Factor Receptor (EGFR) would be proliferative of epithelial cells? multiple answers A. Mutation of active site residue responsible for tyrosine phosphorylation. B. Deletion of extracellular ectodomain C. Mutation in ectodomain that prevents binding of EGF D. Cell expresses EGF E. Mutation in promoter that increases expression of EGF receptor F. Dimerization of receptor without growth factor G. Mutation in EGFR promoter that decreases expression of receptorarrow_forwardEGF signals by binding to cell surface EGF receptors. Which of these observations, if true, would BEST explain EGF’s mechanism of action? A. EGF is hydrophilic and can easily diffuse through the cell membrane B. EGF is hydrophobic and can easily diffuse through the cell membrane C. EGF is hydrophilic and cannot diffuse through the cell membrane D. EGF is hydrophobic and cannot diffuse through the cell membranearrow_forward
- Viagra works on which intra-cellular signaling pathway? a)PLC, DAG, PKC b)RTK, RAS, MAPK c)GPCR, PKB, calmodulin d)Acetylcholine, Nitric Oxide, cGMP e)GPCR, cAMP, PKAarrow_forwardHerceptin is an antibody that is used to treat certain forms of breast cancer by binding to a class of estrogen receptors. What is the basis for its effectiveness in treating certain forms of breast cancer?arrow_forwardA scientist observes a mutation in the transmembrane region of EGFR that eliminates its ability to be stabilized by binding interactions during dimerization after ligand binding. Which hypothesis regarding the effect of this mutation on EGF signaling is most likely to be correct? a. EGF signaling cascades would be active for longer in the cell. b. EGF signaling cascades would be active for a shorter period of time in the cell. c. EGF signaling cascades would not occur. d. EGF signaling would be unaffected.arrow_forward
- Which of these BEST describes how the signal is transduced from the EGF receptor to the Ras protein? A. Ras is phosphorylated B. Ras is dephosphorylated C. Ras binds to a GTP molecule D. Ras hydrolyzes a GTP moleculearrow_forwardLipid-soluble signaling molecules, such as testosterone, cross the membrane of all cells but only affect target cells because a. intracellular receptors are only present in target cells b. only target cells possess the cytosolic enzymes that transduce the testosterone c. target cells are the only cells that can initiate the phosphorylation cascade leading to the transcription factor d. only target cells retain the appropriate DNA segmentsarrow_forwardScaffold proteins (a) release kinases and phosphatases into the extracellular fluid (b) bind G proteins to cell membranes (c) increase accuracy but slow signaling cascades (d) organize groups of intracellular signaling molecules into signaling complexes (e) are transcription factors found mainly in plant cellsarrow_forward
- __________ are molecules released from a signaling cell that have effects on target cells. a. Hormones b. Neurotransmitters c. Local signaling molecules d. Pheromones e. a and b f. all of the abovearrow_forwardThe body produces a normal amount of testosterone. However, a particular cell you are studying has an unusually low number of testosterone receptors. How might the cell's response to testosterone be affected by its low number of testosterone receptors? A. The cell will activate more protein kinases in response to testosterone exposure than a cell with a normal number of testosterone receptors. B. The cell will make less mRNA in response to testosterone exposure. C. The cell will make less cAMP in response to testosterone exposure. D. The cell’s response to testosterone exposure will be identical to the response of a cell with a normal number of testosterone receptors.arrow_forwardOne of the key components in vertebrate limb development is the polarizing region, also known as the zone or polarizing activity of ZPA. Where in the limb bud is this region? What axis of the limb does it help to specify? What properties of this region make it an organizing region Through which signaling molecule does it exert its effects? What is the evidence for the importance of this molecule?arrow_forward
- Biology (MindTap Course List)BiologyISBN:9781337392938Author:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. BergPublisher:Cengage LearningHuman Biology (MindTap Course List)BiologyISBN:9781305112100Author:Cecie Starr, Beverly McMillanPublisher:Cengage LearningBiology 2eBiologyISBN:9781947172517Author:Matthew Douglas, Jung Choi, Mary Ann ClarkPublisher:OpenStax