Human Biology: Concepts and Current Issues Plus Mastering Biology with Pearson eText -- Access Card Package (8th Edition)
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Chapter 19, Problem 7AWK

Nondisjunction during meiosis can lead to the formation of gametes (sperm or eggs) with extra copies of one or more chromosomes. Normally, fertilizations involving extra copies of chromosomes simply do not result in a live birth because too many developmental events are altered in some way. The most common extra-chromosomal condition that does lead to live births is Down syndrome (trisomy 21). Why do you suppose that trisomy 21 is more common than other trisomies?

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Parents pass chromosomes in gametes to form the zygote, which will grow and develop to become an adult. But in the gametes of the adult, each chromosome will be a mix of mothers and father genes, not exclusively mother’s or father’s, as they were in the zygote. Why is this?
Draw a diagram of Metaphase I and II of meiosis in the father, which illustrates the only possible way in which the father’s chromosomes could have aligned during Metaphase I, and in the subsequent Metaphase II in the same cell, in order to have resulted in the conception of the specific son who has all three of these genetic conditions (achondroplasia, color blindness and deafness).
What is chromosomal theory of inheritance? List the ways in which genes and chromosomes behave similarly during meiosis and fertilization. How is sex determined in humans? Which sex determines the sex of the offspring? What are the two types of mutations? What are the four types of changes in chromosomal structure? Why would you expect a monosomy to be more lethal than a trisomy?
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Mitochondrial mutations; Author: Useful Genetics;https://www.youtube.com/watch?v=GvgXe-3RJeU;License: CC-BY