Concept explainers
(a)
Interpretation:
The type of enzyme regulation in which an enzyme becomes overactive during a disease has to be determined.
Concept Introduction:
Enzyme:
- It is a protein or a molecule which can act as a catalyst for a biological reaction.
- Does not affect the equilibrium point of the reaction.
- Active site of the enzyme is the region where the reaction takes place.
- Enzyme’s activity can be specific which means the activity is limited to a certain substrate and a certain type of reaction and it is referred to as specificity of the enzyme.
Enzyme inhibitors: The substance which slows or stops the action of an enzyme is called enzyme inhibitors.
It can be used as drugs and an example is AZT which is used to treat HIV.
The competition of an enzyme can be reversible or irreversible and in reversible inhibition, the inhibitor can leave and in irreversible inhibition, the inhibitor remains permanently bound.
(b)
Interpretation:
The type of enzyme regulation in which an enzyme is needed only when there is low blood glucose has to be determined.
Concept Introduction:
Enzyme:
- It is a protein or a molecule which can act as a catalyst for a biological reaction.
- Does not affect the equilibrium point of the reaction.
- Active site of the enzyme is the region where the reaction takes place.
- Enzyme’s activity can be specific which means the activity is limited to a certain substrate and a certain type of reaction and it is referred to as specificity of the enzyme.
Feedback control: The pathways which are dependent on a series of consecutive reactions in which the product of one reaction is the reactant for the next and these pathways are subjected to feedback control, which occurs when the result of a process feeds information back to affect the beginning process.
(c)
Interpretation:
The type of enzyme regulation in which an enzyme that springs into action when a traumatic injury occurs has to be determined.
Concept Introduction:
Enzyme:
- It is a protein or a molecule which can act as a catalyst for a biological reaction.
- Does not affect the equilibrium point of the reaction.
- Active site of the enzyme is the region where the reaction takes place.
- Enzyme’s activity can be specific which means the activity is limited to a certain substrate and a certain type of reaction and it is referred to as specificity of the enzyme.
Enzyme regulation:
Some enzymes can destroy the organ in which they are produced and they are often synthesized as proenzymes or zymogens.
Enzyme regulation by covalent modification can be done by two methods and one is through removal of a covalently bonded portion of an enzyme or addition of a group.
(d)
Interpretation:
The type of enzyme regulation in which an enzyme is needed only during adolescence has to be determined.
Concept Introduction:
Enzyme:
- It is a protein or a molecule which can act as a catalyst for a biological reaction.
- Does not affect the equilibrium point of the reaction.
- Active site of the enzyme is the region where the reaction takes place.
- Enzyme’s activity can be specific which means the activity is limited to a certain substrate and a certain type of reaction and it is referred to as specificity of the enzyme.
Enzyme regulation by genetic control:
It is a type of control by which regulation of enzyme activity is done by the control of the synthesis of enzymes.
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EP FUND.OF GENERAL,ORG...-MOD.MASTERING
- Explain how the following mechanisms regulate enzyme activity.(a) Covalent modification (b) Genetic control(c) Allosteric regulation (d) Feedback inhibitionarrow_forwardWhich of the following statements is/are correct?a) Enzyme quantities depend on the rate of their synthesis and degradationb) Enzyme quantity is decreased if an amino-acid involved in the catalytic activity is modifiedc) Protein kinase A activity is regulated through protein interaction.d) Kinases control the activity of other enzymes by covalent modification; irreversiblephosphorylation explain each of the following optionarrow_forward. Based on what you know about enzyme inhibition, classify the following examples as irreversible, competitive, or noncompetitive enzyme inhibition. A) competitive B) noncompetitive C) irreversible 1) Diisopropyl fluorophosphate binds to acetylcholinesterase and permanently inactivates the enzyme. Paralysis results. 2) A drug binds to the active site of an enzyme but disassociates and leaves the enzyme active. 3) A toxin binds to the surface of an enzyme. The enzyme then binds the substrate, but no product is produced. The toxin may disassociate and the enzyme will become active again. 4) Vitamin K is a coenzyme involved in blood clotting. An anticoagulant drug binds at the site of vitamin K bonding, blocking vitamin K binding and preventing clotting. Clotting resumes after the patient stops taking the drug. 5) Aspirin binds to prostaglandin synthetase and permanently stops its ability to produce prostaglandin.arrow_forward
- 1. Allosteric regulation is an important part of feedback regulation. All of the functions listed below can be performed by an allosteric molecule EXCEPT: A) catalysis of a reaction. B) activation of an enzyme. C) inhibition of an enzyme. D) conformational change of an enzyme.arrow_forwardWhat type of enzyme regulation is the most readily (quickly) reversible?arrow_forwardB) Read the situations below and indicate which of the four methods of enzyme regulation is occurring for each. a) The energy-carrying molecule ATP is made by the enzyme ATP synthase. Muscle cells use a lot of energy and also have higher amounts of the ATP synthase enzyme than many ouier cem types. General mechanism of enzyme regulation: /1 b) Prostaglandins are messenger molecules involved in the inflammatory response, as well as th perception of pain. They are synthesized from polyunsaturated fatty acid substrates by an enzyn called cyclo-oxygenase. "Ibuprofen" is the active ingredient in a variety of anti-inflammatory medications such as Motrin® and Advil®. It reduces pain and swelling by binding to a hydrophobic channel in the active site of cyclo-oxygenase, blocking the polyunsaturated fatty acids from binding to the enzyme, and therefore stopping production of prostaglandins. General mechanism of enzyme regulation: a) In point form, describe the steps by which ATP is produced…arrow_forward
- What general kinds of reactions do the following types of enzymes catalyze?(a) Kinases (b) Isomerases(c) Synthetasesarrow_forwardQ: Select the features of the structure and functioning of allosteric enzymes: a) are metabolic pathway limiting enzymes b) when interacting with ligands do not show a cooperative effect c) are monomeric proteins d) have spatially separated active and regulatory centers e) do not exhibit regulatory properties during dissociation of the molecule into protomersarrow_forwardWhich 2 endocrine glands exert the most control over blood calcium level:a) anterior pituitary and adrenal cortex b) thyroid and ovaries c) adrenal cortex and thyroid d) parathyroid and anterior pituitary e) thyroid and parathyroidWhat is the role of calcium at the synaptic terminal?Explain the active site theory of enzyme functioning?arrow_forward
- List three ways to alter the rate of an enzyme-mediated reaction.arrow_forwardA competitive inhibitor diminishes the rate of catalysis: A) By reducing the proportion of enzyme molecules bound to a substrate. OB) By altering the shape of the active site of the enzyme C) By binding to a regulatory subunit D) By enhancing the interaction between enzyme and reaction productarrow_forwardWhich one of the following statements about the control of enzyme activity by phosphorylation is correct? a) Phosphorylation of an enzyme results in a conformational change b) Phosphorylation of an enzyme occurs only at specific tyrosine residues c) Phosphorylation of an enzyme is carried out by phosphoprotein phosphatases d) Enzyme control by phosphorylation is irreversiblearrow_forward
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