Concepts of Genetics (12th Edition)
12th Edition
ISBN: 9780134604718
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Textbook Question
Chapter 2, Problem 2CS
Over a period of two years, a man in his early 20s received a series of intermittent chemotherapy and radiotherapy treatments for Hodgkin disease. During this therapy, he and his wife were unable to initiate a pregnancy. The man had a series of his semen samples examined at a fertility clinic. The findings revealed that shortly after each treatment very few mature sperm were present, and abnormal chromosome numbers were often observed in developing spermatocytes. However, such chromosome abnormalities disappeared about 40 days after treatment, and normal sperm reappeared about 74 days post-treatment. Do you think that exposure to chemotherapy and radiotherapy would cause more problems to spermatocytes than to mature sperm?
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A highly talented 22-year-old female college athlete has just qualified to compete in the Summer Olympics. However, when she is required to undergo laboratory testing to measure testosterone levels, she is informed that she will not be permitted to compete because her testosterone levels are “too high for a female athlete”. Further medical and genetic testing reveal that she has a condition known as Complete Androgen Insensitivity Syndrome. She promptly hires an attorney to appeal the decision.
A. What is the chromosomal sex of this female athlete?
B. If she were subjected to a cytological test for the presence of a Barr body or bodies, what would typically be found on such a test performed on an individual having this condition? Please EXPLAIN why this is the case.
Why does a single X chromosome cause infertility and other abnormalities in Turner Syndrome subjects?
On rare occasions, people are born with a condition known as uniparental disomy. It happens when an individual inherits both copies of achromosome from one parent and no copies from the other parent. Thisoccurs when two abnormal gametes happen to complement each otherto produce a diploid zygote. For example, an abnormal sperm thatlacks chromosome 15 could fertilize an egg that contains two copies ofchromosome 15. In this situation, the individual has maternal uniparental disomy 15 because both copies of chromosome 15 were inheritedfrom the mother. Alternatively, an abnormal sperm with two copies ofchromosome 15 could fertilize an egg with no copies. This is known aspaternal uniparental disomy 15. If a female is born with paternal uniparental disomy 15, would you expect her to be phenotypically normal,have Angelman syndrome (AS), or have Prader-Willi syndrome(PWS)? Explain. Would you expect her to produce normal offspring oroffspring affected with AS or PWS?
Chapter 2 Solutions
Concepts of Genetics (12th Edition)
Ch. 2 - With the initial appearance of the feature we call...Ch. 2 - An organism has a diploid number of 16 in a...Ch. 2 - Examine Figure 2.12, which shows oogenesis in...Ch. 2 - Over a period of two years, a man in his early 20s...Ch. 2 - Over a period of two years, a man in his early 20s...Ch. 2 - Over a period of two years, a man in his early 20s...Ch. 2 - In this chapter, we focused on how chromosomes are...Ch. 2 - Review the Chapter Concepts list on page 14. All...Ch. 2 - What role do the following cellular components...Ch. 2 - Discuss the concepts of homologous chromosomes,...
Ch. 2 - If two chromosomes of a species are the same...Ch. 2 - Describe the events that characterize each stage...Ch. 2 - How are chromosomes named on the basis of their...Ch. 2 - Contrast telophase in plant and animal mitosis.Ch. 2 - Describe the phases of the cell cycle and the...Ch. 2 - Define and discuss these terms: (a) synapsis, (b)...Ch. 2 - Contrast the genetic content and the origin of...Ch. 2 - Given the end results of the two types of...Ch. 2 - Contrast spermatogenesis and oogenesis. What is...Ch. 2 - Explain why meiosis leads to significant genetic...Ch. 2 - A diploid cell contains three pairs of homologous...Ch. 2 - Considering Problem 15, predict the number of...Ch. 2 - During oogenesis in an animal species with a...Ch. 2 - What is the probability that, in an organism with...Ch. 2 - The nuclear DNA content of a single sperm cell in...Ch. 2 - Describe the role of meiosis in the life cycle of...Ch. 2 - Contrast the chromatin fiber with the mitotic...Ch. 2 - Describe the folded-fiber model of the mitotic...Ch. 2 - Prob. 23PDQCh. 2 - If one follows 50 primary oocytes in an animal...Ch. 2 - In mitosis, what chromatid combination(s) will be...Ch. 2 - During meiosis I, assuming no crossing over, what...Ch. 2 - Are there any possible combinations present during...Ch. 2 - Draw all possible combinations of chromatids...Ch. 2 - Assume that during meiosis I none of the C...Ch. 2 - Assume that each gamete resulting from Problem 29...Ch. 2 - A species of cereal rye (Secale cereale) has a...Ch. 2 - An interesting procedure has been applied for...Ch. 2 - Assume that you were examining a first polar body...Ch. 2 - Kuliev and Verlinsky (2004) state that there was a...
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- Human sex chromosomes are XX for females and XY for males. a. With respect to an X-linked gene, how many different types of gametes can a male produce? b. If a female is homozygous for an X-linked allele, how many different types of gametes can she produce with respect to this allele? c. If a female is heterozygous for an X-linked allele, how many different types of gametes can she produce with respect to this allele?arrow_forwardJan is concerned about using ART. She wants to be the genetic mother and have Darryl be the genetic father of any children they have. What methods of ART would you recommend to this couple? Jan, a 32-year-old woman, and her husband, Darryl, have been married for 7 years. They have attempted to have a baby on several occasions. Five years ago, they had a first-trimester miscarriage, followed by an ectopic pregnancy later the same year. Jan continued to see her OB/GYN physician for infertility problems but was very dissatisfied with the response. After four miscarriages, she went to see a fertility specialist, who diagnosed her with severe endometriosis and polycystic ovarian disease (detected by hormone studies). The infertility physician explained that these two conditions were hampering her ability to become pregnant and thus making her infertile. She referred Jan to a genetic counselor. At the appointment, the counselor explained to Jan that one form of endometriosis (MIM 131200) can be a genetic disorder, and that polycystic ovarian disease can also be a genetic disorder (MIM 184700) and is one of the most common reproductive disorders among women. The counselor recommended that a detailed family history of both Jan and Darryl would help establish whether Jans problems have a genetic component and whether any of her potential daughters would be at risk for one or both of these disorders. In the meantime, Jan is taking hormones, and she and Darryl are considering alternative modes of reproduction. Using the information in Figure 16.4, explain the reproductive options that are open to Jan and Darryl.arrow_forwardWhat is the probability for a spermatozoid to receive only maternal chromosomes (that were given by the mother of this man) ?arrow_forward
- A company that offers PGD terms an embryo “normal and healthy” if it has 46 chromosomes. Why is this statement misleading? , Two famous male actors had twins using a surrogate mother who carried two embryos that hadbeen fertilized in vitro, one with one man’s sperm and the other with the other man’s sperm. In terms of genetics, how closely are the babies, a boy and a girl, related to each other if they have different fathers?arrow_forward1. Maurice was born with an XY chromosome type, and he has the external genitalia of a male. He has, for the better part of his life, however, felt like he was supposed to be a woman. He has always identified more with feminine clothes, behaviors, and emotions. According to chapter 10 in your textbook, Maurice has a male __________. 2. Maurice was born with an XY chromosome type, and he has the external genitalia of a male. He has, for the better part of his life, however, felt like he was supposed to be a woman. He has always identified more with feminine clothes, behaviors, and emotions. According to chapter 10 in your textbook, Maurice has a female __________. 3. __________ is a biological phenomenon, while __________ is a socially constructed phenomenon. 4. A young boy develops facial and chest hair, pubic hair, and an enlarged Adam’s apple. This happens because puberty is stimulating the development of his ______.arrow_forwardResearchers discovered recently that the sole functionof the SRY protein is to activate an autosomal genecalled Sox9 in the presumptive gonad (before it has“decided” to become a testis or an ovary).a. What would be the sex of an XY individual homozygous for nonfunctional mutant alleles of Sox9?Explain.b. Given your answer to part (a), why is SRY, ratherthan Sox9, considered the male determining factor?(Hint: What do you think would happen if you didan experiment like the one in the Fast Forward BoxTransgenic Mice Prove That SRY Is the MalenessFactor, except that you used a Sox9 transgeneinstead of SRY?)arrow_forward
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