ESSENTIALS OF GENETICS-W/MOD.ACCESS
9th Edition
ISBN: 9780134452876
Author: KLUG
Publisher: PEARSON
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Chapter 20, Problem 17PDQ
Dominguez et al. (2004) suggest that by studying genes that determine growth and tissue specification in the eye of Drosophila, much can be learned about human eye development.
(a) What evidence suggests that genetic eye determinants in Drosophila are also found in humans? Include a discussion of orthologous genes in your answer.
(b) What evidence indicates that the eyeless gene is part of a developmental network?
(c) Are genetic networks likely to specify developmental processes in general? Explain fully and provide an example.
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Dominguez et al. (2004) suggest that by studying genes that determine growth and tissue specification in the eye of Drosophila, much can be learned about human eye development. (a) What evidence suggests that genetic eye determinants in Drosophila are also found in humans? Include a discussion of orthologous genes in your answer. (b) What evidence indicates that the eyeless gene is part of a developmental network?
Compare and contrast the experimental advantages and disadvantages of Drosophila, C. elegans, mammals, and Arabidopsis.
How have we discovered that specific genes control development in an organism like Drosophila?
Chapter 20 Solutions
ESSENTIALS OF GENETICS-W/MOD.ACCESS
Ch. 20 -
CASE STUDY |One foot or another
In humans the...Ch. 20 - CASE STUDY| One foot or another In humans the HOXD...Ch. 20 - CASE STUDY| One foot or another In humans the HOXD...Ch. 20 - HOW DO WE KNOW? In this chapter, we have focused...Ch. 20 - Review the Chapter Concepts list on page 403. Most...Ch. 20 -
3. Nuclei from almost any source may be injected...Ch. 20 -
4. Distinguish between the syncytial blastoderm...Ch. 20 - (a) What are maternal-effect genes? (b) When are...Ch. 20 - (a) What are zygotic genes, and when are their...Ch. 20 - List the main classes of zygotic genes. What is...
Ch. 20 -
8. Experiments have shown that any nuclei placed...Ch. 20 - How can you determine whether a particular gene is...Ch. 20 -
10. You observe that a particular gene is being...Ch. 20 - What are Hox genes? What properties do they have...Ch. 20 -
12. The homeotic mutation Antennapedia causes...Ch. 20 - The Drosophila homeotic mutation spineless...Ch. 20 - A number of genes that control expression of Hox...Ch. 20 - In Arabidopsis, flower development is controlled...Ch. 20 - Prob. 16PDQCh. 20 - Dominguez et al. (2004) suggest that by studying...
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- In the late 1980s, this gradient hypothesis was united with a genetic approach to the study of Drosophila embryogenesis. If there were gradients, what were the morphogens whose concentrations changed over space?arrow_forwardFirst, concerningthe evolution of development, what have been the changes in developmentalmechanisms that give rise to different phenotypes? A second question, closelyrelated to the first, is how do genetic differences among species map onto phenotypic differences? Third, what is the role of development in either constraining or enhancing evolutionary change in characters? That is, how does development affect “evolvability”? Fourth, how does developmental information help usidentify homologous characters, or even define homology? Finally, can understanding development help us understand the origin of novel characteristics?arrow_forwardHow are the mammalian Hox genes related to the homeotic genes of Drosophila? How do the Hox genes contribute to morphological diversity in vertebrates, give an example.arrow_forward
- What is positional information? Discuss three different ways that cells obtain positional information. Which of these three ways do you think is the most important for the formation of a segmented body pattern in Drosophila?arrow_forwardYou isolate a glp-1 mutation of C. elegans and discoverthat the DNA region encoding the spatial control region(SCR) has been deleted. What will the GLP-1 protein expression pattern be in a four-cell embryo in mutant heterozygotes? In mutant homozygotes?arrow_forwardWhat is the function of the Pax 6 gene in the mouse eye reference to HOX gene?arrow_forward
- Christiane Nüsslein-Volhard and her colleagues carried out several experiments in an attempt to understand what determines the anterior and posterior ends of a Drosophila larva (reviewed in C. Nüsslein- Volhard, H. G. Frohnhofer, and R. Lehmann. 1987. Science 238:1675– 1681). They isolated fruit flies with mutations in the bicoid gene (bcd−). These flies produced embryos that lacked a head and thorax. When they transplanted cytoplasm from the anterior end of an egg from a wild-type female into the anterior end of an egg from a mutant bicoid female, normal head and thorax development took place in the embryo. However, transplanting cytoplasm from the posterior end of an egg from a wild-type female into the anterior end of an egg from a bicoid female had no effect. Explain these results in regard to what you know about proteins that control the determination of the anterior–posterior axis.arrow_forwardCompare and contrast how maternal-effect genes, gap genes, and homeotic genes affect Drosophila development.arrow_forwardWhat controls hox genes expression in vertebrates?arrow_forward
- Christiane Nüsslein-Volhard and her colleagues carried out several experiments in an attempt to understand what determines the anterior and posterior ends of a Drosophila larva (reviewed in C. NüssleinVolhard, H. G. Frohnhofer, and R. Lehmann. 1987. Science 238:1675– 1681). They isolated fruit flies with mutations in the bicoid gene (bcd−). These flies produced embryos that lacked a head and thorax. When they transplanted cytoplasm from the anterior end of an egg from a wild-type female into the anterior end of an egg from a mutant bicoid female, normal head and thorax development took place in the embryo. However, transplanting cytoplasm from the posterior end of an egg from a wild-type female into the anterior end of an egg from a bicoid femalehad no effect. Explain these results in regard to what you know about proteins that control the determination of the anterior–posterior axis.arrow_forwardDiscuss the role of homeotic genes in development. Explain what happens to the phenotype of a fruit fly when a gain-of-function mutation in a homeotic gene causes the protein to be expressed in an abnormal region of the embryo. What are the consequences of a loss-of-function mutation in such a gene?arrow_forwardExplain hoxA3 and HoxD3 genes are nearly equivalent yet they play distinct roles in the development of mouse.arrow_forward
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