BIOCHEMISTRY-ACHIEVE (1 TERM)
9th Edition
ISBN: 9781319402853
Author: BERG
Publisher: MAC HIGHER
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Chapter 20, Problem 29P
Interpretation Introduction
Interpretation:
The fate of the radioactive labeled glucose with
Concept introduction:
The
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disease. As such, a frontline treatment for Type 2 diabetes is the drug metformin, which acts indirectly
to inhibit gluconeogenesis in the liver. You are a research biochemist who would like to develop new
drugs that act to directly inhibit gluconeogenesis. You have just gained access to a library of thousands
of small molecules of unknown activity, and you would like to identify lead compounds that have specific
inhibitory activity against steps in the gluconeogenesis pathway.
(a)
into PEP in order to screen for inhibitors of enzymes specific to gluconeogenesis. Which enzymes do
you need to purify, what cofactors and allosteric effectors do they require, and which reactants do you
need to add to reconstitute the reactions for the first bypass? Which intermediates and products are
generated?
Your first approach is to reconstitute the initial set of bypass reactions that convert pyruvate
(b)
vitro reconstitution?
What additional steps and enzymes are required in liver cells but are…
Instructions.
Given each set of information which may include common name(s) and the reaction catalyzed, you are required to identify the main class of the specific enzyme described.
Name: citryl-CoA synthetase
Reaction: ATP + citrate + CoA = ADP + phosphate + (3S)-citryl-CoA
Name: D-xylulose reductase
Reaction: xylitol + NAD+ = D-xylulose + NADH + H+
Name: cellobiose phosphorylase
Reaction: cellobiose phosphate = α-D-glucose 1-phosphate + D-glucose
Name: carbonic anhydrase
Reaction: H2CO3 = CO2 + H2O
Other info: The enzyme catalyzes the reversible hydration of gaseous CO2 to carbonic acid, which dissociates to give hydrogencarbonate above neutral pH.
Name: pantoate activating enzyme
Reaction: ATP + (R)-pantoate = AMP + diphosphate + (R)-pantothenate.
Please ASA. Thanku.
In the reaction Na + Cl à Na+ + Cl-, which component is said to become ‘oxidized’ and which is considered reduced?
Na, Cl
Cl, Cl
Na, Na
Cl, Na
Chapter 20 Solutions
BIOCHEMISTRY-ACHIEVE (1 TERM)
Ch. 20 - Prob. 1PCh. 20 - Prob. 2PCh. 20 - Prob. 3PCh. 20 - Prob. 4PCh. 20 - Prob. 5PCh. 20 - Prob. 6PCh. 20 - Prob. 7PCh. 20 - Prob. 8PCh. 20 - Prob. 9PCh. 20 - Prob. 10P
Ch. 20 - Prob. 11PCh. 20 - Prob. 12PCh. 20 - Prob. 13PCh. 20 - Prob. 14PCh. 20 - Prob. 15PCh. 20 - Prob. 16PCh. 20 - Prob. 17PCh. 20 - Prob. 18PCh. 20 - Prob. 19PCh. 20 - Prob. 20PCh. 20 - Prob. 21PCh. 20 - Prob. 22PCh. 20 - Prob. 23PCh. 20 - Prob. 24PCh. 20 - Prob. 25PCh. 20 - Prob. 26PCh. 20 - Prob. 27PCh. 20 - Prob. 28PCh. 20 - Prob. 29PCh. 20 - Prob. 30PCh. 20 - Prob. 31PCh. 20 - Prob. 32PCh. 20 - Prob. 33PCh. 20 - Prob. 34PCh. 20 - Prob. 35PCh. 20 - Prob. 36PCh. 20 - Prob. 37PCh. 20 - Prob. 38PCh. 20 - Prob. 39PCh. 20 - Prob. 40PCh. 20 - Prob. 41PCh. 20 - Prob. 42PCh. 20 - Prob. 43PCh. 20 - Prob. 44PCh. 20 - Prob. 45PCh. 20 - Prob. 46PCh. 20 - Prob. 47PCh. 20 - Prob. 48P
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