Interpretation: The reason corresponding to the fact that organolithium reagents are not used to generate enolates is to be stated.
Concept Introduction: The substitution reaction involves the replacement of one functional group by other functional group. In nucleophilic substitution an electron rich species attack the species that is deficient in electrons. The electrophile and the leaving group together form a substrate. The nucleophile attacks over the substrate and there occurs the removal of leaving group from the substrate.
The nucleophilic reaction that consists of bimolecular as well as bond-making and bond-breaking steps is termed as
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Organic Chemistry (6th Edition)
- Write the reagents and reaction conditions that are necessary for each of the following transformations.arrow_forwardDraw the enol intermediate formed for this reactionarrow_forwardWhat is the source of the nucleophilic attack? How does the oxygen get protonated? What causes the elimination reaction?arrow_forward
- The following compound may be synthesized through alkylation of an appropriate enamine with an alkyl bromide, followed by hydrolysis of the resulting immonium ion. Using this strategy, provide the necessary starting materials for the synthesis. (Note that a portion of the starting enamine is given.)arrow_forward4. WHAT ARE IMINES? HOW ARE THEY FORMED? 5. WHAT IS GRIGNARD REACTION? WHAT CONSTITUTES A GRIGNARD REAGENT? 6. WHAT IS KETO-ENOL TAUTOMERIZATION?arrow_forwardChoose the best reagents to complete the following reaction.arrow_forward
- Organic Chemistry: A Guided InquiryChemistryISBN:9780618974122Author:Andrei StraumanisPublisher:Cengage Learning