Interpretation:
Mechanisms for the three steps involved in the trapping of β- lactamase by tazobactum such as a) the reaction of the hydroxyl group on the β- lactamase to open the β- lactum ring of tazobactum b) The opening of the sulfur-containing ring in tazobactum to give an acyclic imine intermediate c) Cyclization of the imine intermediate to yield trapped β- lactamase product are to be proposed.
Concept introduction:
Three steps are involved in the conversion required. i ) Nucleophilic attack of β- lactamase on tazobactum to open the β- lactum ring ii) Formation of an imine intermediate by opening of the sulfur-containing ring in tazobactum iii) Cyclization to yield the trapped β- lactamase. All the three reactions involve the attack of nucleophiles.
To propose:
Mechanisms for the three steps involved in the trapping of β- lactamase by tazobactum such as a) the reaction of the hydroxyl group on the β- lactamase to open the β- lactum ring of tazobactum b) The opening of the sulfur-containing ring in tazobactum to give an acyclic imine intermediate c) Cyclization of the imine intermediate to yield trapped β- lactamase product.
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Organic Chemistry
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- Organic ChemistryChemistryISBN:9781305580350Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. FootePublisher:Cengage Learning