Essentials of Genetics Plus Mastering Genetics with eText -- Access Card Package (9th Edition) (Klug et al. Genetics Series)
9th Edition
ISBN: 9780134047201
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino
Publisher: PEARSON
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Chapter 22, Problem 17PDQ
Achondroplasia is a dominant trait that causes a characteristic form of dwarfism. In a survey of 50,000 births, five infants with achondroplasia were identified. Three of the affected infants had affected parents, while two had normal parents. Calculate the mutation rate for achondroplasia and express the rate as the number of mutant genes per given number of gametes.
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Achondroplasia is a dominant trait that causes a characteristicform of dwarfism. In a survey of 50,000 births, five infants withachondroplasia were identified. Three of these infants had parentswith achondroplasia, while two did not. Calculate the mutationrate for achondroplasia, and express the rate as the numberof mutant genes per given number of gametes.
You find a person that has a new allele that is not found in DNA samples taken from skin cells of the mother or the father, suggesting that the mutation arose during the formation of the gametes that formed this person. Is it more likely that the mutation was present in the sperm or the egg that formed this person and why do you believe this is the case?”
A couple who are both heterozygous for an autosomal recessive mutation that is narrowly expressed and fully penetrant are planning on having three children. What is the probability that one their children will be normal (unaffected) and two children will have the recessive mutant phenotype? Show your work. Please answer this question using the Bayes’ Theorem
Chapter 22 Solutions
Essentials of Genetics Plus Mastering Genetics with eText -- Access Card Package (9th Edition) (Klug et al. Genetics Series)
Ch. 22 - CASE STUDY |An unexpected outcome A newborn...Ch. 22 - CASE STUDY |Anunexpected outcome A newborn...Ch. 22 - CASE STUDY|An unexpected outcome A newborn...Ch. 22 - HOW DO WE KNOW? Population geneticists study...Ch. 22 - Review the Chapter Concepts on page 441. All these...Ch. 22 -
3. Price et al. (1999. J. Bacteriol. 181:...Ch. 22 -
4. The genetic difference between two Drosophila...Ch. 22 - The use of nucleotide sequence data to measure...Ch. 22 - Calculate the frequencies of the AA, Aa, and aa...Ch. 22 - Prob. 7PDQ
Ch. 22 -
8. What must be assumed in order to validate the...Ch. 22 - In a population where only the total number of...Ch. 22 -
10. If 4 percent of a population in equilibrium...Ch. 22 -
11. Consider a population in which the frequency...Ch. 22 - If the initial allele frequencies are p = 0.5 and...Ch. 22 -
13. Under what circumstances might a lethal...Ch. 22 - Assume that a recessive autosomal disorder occurs...Ch. 22 -
15. One of the first Mendelian traits identified...Ch. 22 -
16. Describe how populations with substantial...Ch. 22 - Achondroplasia is a dominant trait that causes a...Ch. 22 -
18. A recent study examining the mutation rates...Ch. 22 - A form of dwarfism known as Ellis–van Creveld...Ch. 22 -
20. List the barriers that prevent interbreeding...Ch. 22 - What are the two groups of reproductive isolating...Ch. 22 - Prob. 22PDQCh. 22 -
23. In a recent study of cichlid fish inhabiting...Ch. 22 - What genetic changes take place during speciation?Ch. 22 - Some critics have warned that the use of gene...Ch. 22 - Comparisons of Neanderthal mitochondrial DNA with...
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Theodor Boveri predicted that malignancies would often be associated with chromosomal mutation. What lines of evidence substantiate this prediction?arrow_forwardWhich of the following disorders in humans has an X-linked recessive inheritance pattern? a.Hutchinson-Gilford progeria b.Tay-Sachs disease c.Marfan syndrome d.Red-green color blindness Which of the following is described as a structural rearrangement of a chromosome in which a broken piece has become reattached in the wrong location? a.Duplication b.Translocation c.Inversion d.Deletion Which of the following disorders arises from translocation events? a.Huntington’s disease b.Infertility c.Burkitt lymphoma d.Duchenne muscular dystrophyarrow_forwardLocus heterogeneity means that a genetic disordera. has a heterogeneous phenotype.b. is caused by mutations in two or more different genes.c. involves a structural change in multiple chromosomes.d. is inherited from both parentsarrow_forward
- Suppose genetic analysis reveals a serious mutation in a gene in the green region of the left-hand copy of chromosome 9 in this individual. Where would you go look for another allele of this gene in this individual to see whether this individual is homozygous or heterozygous for this mutation?arrow_forwardTo determine whether radiation associated with the atomic bombings of Hiroshima and Nagasaki produced recessive germ-line mutations, scientists examined the sex ratio of the children of the survivors of the blasts. Can you explain why an increase in germ-line mutations might be expected to alter the sex ratio?arrow_forwardLocus heterogeneity refers to a genetic disorder thata. has a heterogeneous phenotype.b. is caused by mutations in two or more different genes.c. involves a structural change in multiple chromosomes.d. is inherited from both parents.arrow_forward
- Red-green color blindness is caused by a mutation in the gene coding for one the Ospin proteins which are needed for color Vision the diagram in the image shows the inheritance of red-green color blindness in one family. person 12 is pregnant with her forth child, what is the probability that this child will be a male with red-green color blindness explain the answer by drawing a genetic diagram using the following symbols in the second image.arrow_forwardUntil very recently, the fitness of an individual getting familial retinoblastoma was zero, and if the frequency of babies with the inherited disease is 1/20000, what is the best estimate of the mutation rate of the wild type allele to the non-functional form?arrow_forwardNullisomy is a genome mutation where a pair of homologous chromosomes that would normally be present is ______.arrow_forward
- In the fruit fly, recessive mutations in either of two independently assorting genes, brown and purple, prevent the synthesis of red pigment in the eyes. Thus, homozygotes for either of these mutations have brownish-purple eyes. However, heterozygotes for both of these mutations have dark red, that is, wild-type eyes. If such double heterozygotes are intercrossed, what kinds of progeny will be produced, and in what proportions?arrow_forward“In an organism that reproduces asexually, there is no difference between a somatic cell mutation and a germ line mutation.” Is this statement true? Explain.arrow_forwardTay Sachs is a rare autosomal recessive disorder that causes mental and physical disabilities leading to death in infants. Affected individuals are lacking the enzyme hexosaminidase, causing lipids to build up in the brain.The HEXA gene on chromosome 15 codes for hexosaminidase, and a four base pair insertion in the gene results in an altered reading frame and non-functional enzyme being produced. Individuals who are carriers (heterozygotes) of the Tay-Sachs allele are not affected by the disease but appear to have increased protection against tuberculosis.The incidence of Tay-Sachs disease is much higher among Ashkenazi Jews originating from Eastern Europe than the general population of the United States. About 1 in 3 500 babies of Ashkenazi Jewish heritage are born with Tay-Sachs disease and about 1 in 30 Ashkenazi Jews are carriers compared to about 1 in 320 000 babies born with the disease and about 1 in 300 carriers in the general United States population. Ashkenazi Jews living in…arrow_forward
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