Fundamentals of Biochemistry: Life at the Molecular Level
Fundamentals of Biochemistry: Life at the Molecular Level
5th Edition
ISBN: 9781118918401
Author: Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher: WILEY
Question
Book Icon
Chapter 22, Problem 1E
Summary Introduction

To explain: The advantages of having increased levels of GLUT1 and phosphofructokinase in muscles for the adaptation in high altitudes.

Concept introduction: GLUT 1 stands for glucose transporter 1, also called as solute carrier family 2. It was the first glucose transporter to be characterized. It helps in the transport of glucose across the plasma membrane of the mammalian cells. Phosphofructokinase is an enzyme that phosphorylates fructose 6-phosphate in the glycolysis.

Expert Solution & Answer
Check Mark

Explanation of Solution

The lower air pressure in the high altitudes makes it more difficult for oxygen to enter the vascular systems. Therefore, oxygen availability for the aerobic metabolism is low. In these conditions, the anaerobic pathway glycolysis will become more important in the active muscles. Glucose transporter 1 transports the glucose across the plasma membrane. The increase in GLUT 1 increases the intracellular glucose concentration. An increase in level of the enzyme phosphofructokinase increases the flux of glucose through the pathway.

Want to see more full solutions like this?

Subscribe now to access step-by-step solutions to millions of textbook problems written by subject matter experts!
Knowledge Booster
Background pattern image
Recommended textbooks for you
Text book image
Biochemistry
Biochemistry
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:W. H. Freeman
Text book image
Lehninger Principles of Biochemistry
Biochemistry
ISBN:9781464126116
Author:David L. Nelson, Michael M. Cox
Publisher:W. H. Freeman
Text book image
Fundamentals of Biochemistry: Life at the Molecul...
Biochemistry
ISBN:9781118918401
Author:Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:WILEY
Text book image
Biochemistry
Biochemistry
ISBN:9781305961135
Author:Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal
Publisher:Cengage Learning
Text book image
Biochemistry
Biochemistry
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Cengage Learning
Text book image
Fundamentals of General, Organic, and Biological ...
Biochemistry
ISBN:9780134015187
Author:John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher:PEARSON