(a)
Interpretation: The synthesis of given analgesic compound from phenol and any other organic or inorganic reagents is to be stated.
Concept introduction: The replacement or substitution of one functional group with another different functional group in any
(b)
Interpretation: The synthesis of given analgesic compound from phenol and any other organic or inorganic reagents is to be stated.
Concept introduction: The replacement or substitution of one functional group with another different functional group in any chemical reaction is termed as substitution reaction. The electron rich chemical species that contains negative charge or lone pair of electrons are known as nucleophile. In nucleophilc acyl substitution reaction, nucleophile takes the position of leaving group.
(c)
Interpretation: The synthesis of given analgesic compound from phenol and any other organic or inorganic reagents is to be stated.
Concept introduction: The replacement or substitution of one functional group with another different functional group in any chemical reaction is termed as substitution reaction. The electron rich chemical species that contains negative charge or lone pair of electrons are known as nucleophile. In nucleophilc acyl substitution reaction, nucleophile takes the position of leaving group.
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ORGANIC CHEMISTRY
- Draw the product formed when phenylacetic acid (C6H5CH2COOH) is treated with each reagent. With some reagents, no reaction occurs. a. NaHCO3 b. NaOH c. SOCl2 d. NaCl e. NH3(1equiv) f. NH3, ∆ g. CH3OH, H2SO4 h. CH3OH, −OH i. [1] NaOH; [2] CH3COCl j. CH3NH2, DCC k. [1] SOCl2; [2] CH3CH2CH2NH2 (excess) l. [1] SOCl2; [2] (CH3)2; [2] (CHarrow_forwardWhat starting materials are needed to prepare each drug using reductive amination? Give all possible pairs of compounds when more than one route is possible.arrow_forwardIn the 1880's, Acetanilide, sold under the name Antifebrin, was widely used as a pain reliever and fever reducer. However, it had many adverse side effects, including cyanosis as a result of methemoglobinemia. The toxic side effects were the result of a small portion of acetanilide being hydrolyzed to aniline. Acetanilide was discontinued and replaced with phenacetin. Later studies show that both acetanilide and phenacetin are metabolized to acetaminophen. This metabolite, which we know as Tylenol, is responsible for the analgesic and antipyretic properties. Part 1: Show a detailed arrow pushing mechanism of the acid catalyzed hydrolysis of acetanilide to aniline Part 2: Propose a synthesis of Acetaminophen from phenol NH NH NH Phenacetin inophen Acetanilide Attach File Browse Local Files Browse Content Collectionarrow_forward
- Acetal and Hemiacetal formation: c. Acetal/hemiacetal CH 3 ty CH H3C [ a. hemiacetal H3C d. Cyclic hemiacetal Gyertych OH Esterification/Amidation: e. Fisher esterification OH + CH₂OH + H3C CH3 H OH + CH3OH H [H*] H₂SO4 H™ a. hemiacetal b.acetal + H₂Oarrow_forwardWhat alkyl halide is needed to prepare each 1° amine by the Gabriel synthesis?arrow_forwardProduct to all parts ?arrow_forward
- 1. Why is acetanilide no longer available as a drug in the market? 2. Why is the synthesis of acetanilide still relevant? 3. Can acetanilide be re-offered to market again?arrow_forwardIdentify the keto form of each enol tautomer. A. HO. H. B. OH C. HO A1 D. В1 C1 D1 C2 Resetarrow_forwardDraw the product formed when CH3CH2CH2CH2NH2 reacts with each carbonyl compound in the presence of mild acidarrow_forward
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