Concept explainers
(a)
Interpretation:
The major product of the given crossed Claisen condensation has to be stated.
Concept introduction:
In crossed claisen condensation, the enolisable ester is deprotonated by alkoxide ion. This enolate ion undergoes a nucleophilic acyl substitution with non-enolisable ester to give a beta-keto ester. It is deprotonated by an alkoxide ion followed by protonation to give beta-keto ester. In this reaction, the electrophilic component is ester without alpha hydrogens.
(b)
Interpretation:
The major product of the given crossed Claisen condensation is to be stated.
Concept introduction:
In crossed claisen condensation, the enolisable ester is deprotonated by alkoxide ion. This enolate ion undergoes a nucleophilic acyl substitution with non-enolisable ester to give a beta-keto ester. It is deprotonated by an alkoxide ion followed by protonation to give beta-keto ester. In this reaction, the electrophilic component is ester without alpha hydrogens.
(c)
Interpretation:
The major product of the given crossed Claisen condensation is to be stated.
Concept introduction:
In crossed claisen condensation, the enolisable ester is deprotonated by alkoxide ion. This enolate ion undergoes a nucleophilic acyl substitution with non-enolisable ester to give a beta-keto ester. It is deprotonated by an alkoxide ion followed by protonation to give beta-keto ester. In this reaction, the electrophilic component is ester without alpha hydrogens.
Want to see the full answer?
Check out a sample textbook solutionChapter 22 Solutions
EP ORGANIC CHEMISTRY -MOD.MASTERING 18W
- As we will learn in Chapter 9, an epoxide is an ether with an oxygen atom in a three-membered ring. Epoxides can be made by intramolecular SN2 reactions of intermediates that contain a nucleophile and a leaving group on adjacent carbons, as shown.Assume that each of the following starting materials can be converted to an epoxide by this reaction. Draw the product formed (including stereochemistry) from each starting material. Why might some of these reactions be more difficult than others in yielding nucleophilic substitution products?arrow_forwardWhich of the following statements best describes the general reactivity of alkynes? O An alkyne reacts as an electrophile and is therefore electron poor. O An alkyne reacts as an electrophile and is therefore electron rich. O An alkyne reacts as a nucleophile and is therefore electron poor. O An alkyne reacts as a nucleophile and is therefore electron rich. O Alkynes fail to undergo electrophilic addition reactions, unlike alkenes.arrow_forwardDraw the major E2 elimination products from each of the attached alkyl halides.arrow_forward
- Devise concise syntheses for the following transformations. Clearly show the reagent and product foreach step.arrow_forwardWhich of the following is capable of producing longer alkyne products? a Internal alkyne with NaNH2 and Alkyl halides b Terminal alkyne with NaNH2 and Alkyl halides c Internal alkene with NaNH2 and Alkyl halides d Terminal alkene with NaNH2 and Alkyl halidesarrow_forwardSynthesize the following compound from cyclohexanone and any other organic and inorganic reagents you need.arrow_forward
- The following reaction can be classified as: elimination acid rearrangement substitution additionarrow_forwardDraw the major E2 elimination products from each of the following alkyl halides.arrow_forwardAlkyl diazonium salts decompose to form carbocations, which go on to form products of substitution, elimination, and (sometimes)rearrangement. Keeping this in mind, draw a stepwise mechanism thatforms all of the following productsarrow_forward