(a)
Interpretation:
The validation of the fact that the given compound cannot be synthesized by acetoacetic ester synthesis is to be stated with an explanation.
Concept introduction:
The final products of acetoacetic ester synthesis are
(b)
Interpretation:
The compound shown in part (a) is to be synthesized from 1,3-diphenylacetone.
Concept introduction:
LDA (Lithium Di-isopropyl Amide) is a strong base with a molecular formula,
(c)
Interpretation:
The compound shown in part (b) is to be synthesized from 1,3-diphenylacetone using enamine reaction.
Concept introduction:
When a ketone reacts with a secondary
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EP ORGANIC CHEMISTRY -MOD.MASTERING 18W
- i) Primary amines react rapidly with acid chlorides. Illustrate such a reaction by drawing the curly arrow mechanism for the reaction between butylamine and benzoyl chloride (C6H5COCl). 2. What kind of carbonyl compound is produced? 3. In the above experiment, why is a non-nucleophilic base such as triethylamine typically added to the reaction mixture?arrow_forwardThe cyclic ester (lactone) Exaltolide has a musk-like fragrance and is used as a fixative in perfumery. Show how this compound could be synthesized from the indicated starting material. Give the structure of R. COR Exaltolidearrow_forwardWhat reaction sequence will form dibenylamine from benzoic acid in high yieldarrow_forward
- In an Electrophilic Aromatic Reaction explain: 1. why the –NHCOCH3 group in acetanilide is only moderately activating while the -NH2 group in aniline is strongly activating? 2.Also explain why in a Electrophilic Aromatic Reaction why potassium bromate is used in this reaction instead of Br2 directly?arrow_forwardMatch the given product to its possible reaction. HO HO H₂N Choose... Choose... Aminolysis of benzoic acid Hydrolysis of benzoyl chloride Oxidation of benzoic acid Nucleophilic acyl substitution of benzoic acid with cyclopropane carboxylate Cleavage reaction using ozone in hydrogen peroxide Electrophilic addition of chlorine in ferric chloride Esterification of benzoic acid by addition of propanol Reduction of benzoic acid Choose... Choose... Choose... 45 « 47 «arrow_forward30. The following molecule is susceptible to nucleophilic attack at the carbonyl carbon as well as two other positions. Provide an explanation for this observation (structures would be useful).arrow_forward
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- N-Methylbenzamide, an isomer of acetanilide, when allowed to react with HNO3/H2SO4 gives a different product from what is obtained from acetanilide. What is the structure of the mononitrated product? Why is it produced?arrow_forwardExplain why imidazolides are much more reactive than other amides in nucleophilic acyl substitution.arrow_forward17. Show how you would synthesize the reactions. a.arrow_forward
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