Pearson eText Human Physiology: An Integrated Approach -- Instant Access (Pearson+)
8th Edition
ISBN: 9780135212905
Author: Dee Silverthorn
Publisher: PEARSON+
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Chapter 23, Problem 14RQ
One diagnostic test to determine the cause of hypercortisolism is a dexamethasone suppression test. Dexamethasone blocks secretion of ACTH by the pituitary. The following table shows the results from two patients given a dexamethasone suppression test.
Can you tell from these results where the patients’ pathologies originate? Explain for each patient.
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Cushing’s syndrome is a disorder that occurs when your adrenal glands release too much cortisol.Sometimes, Cushing’s is caused by a hormone-secreting tumor that leads to dysregulation of the hypothalamus-pituitary-adrenal gland axis. Below, are listed a few tests doctors perform to determine the specific cause of Cushing’s in each patient. Please read the description of the test and possible results and respond to the prompts below. 1 Measure blood levels of adrenocorticotropic hormone (ACTH). If ACTH levels are lower than normal, where is the tumor? How do you know? Remember, this person has high cortisol levels 2 Conduct a corticotropin-releasing hormone (CRH) stimulation test where you inject a shot of CRH. If this test results in a normal increase in ACTH levels, where is the tumor? How do you know? 3 Inject a very high-dose of compound that is a cortisol-receptor agonist. A few hours later measure levels of circulating ACTH. If the test results in normal…
Chapter 23 Solutions
Pearson eText Human Physiology: An Integrated Approach -- Instant Access (Pearson+)
Ch. 23.2 - Prob. 1CCCh. 23.2 - Prob. 2CCCh. 23.2 - What do the abbreviations HPA and CBG stand for?...Ch. 23.2 - Prob. 4CCCh. 23.2 - Prob. 5CCCh. 23.2 - Prob. 6CCCh. 23.2 - Would someone with Addisons disease have normal,...Ch. 23.2 - Prob. 8CCCh. 23.3 - A woman who had her thyroid gland removed because...Ch. 23.3 - Prob. 10CC
Ch. 23.4 - Prob. 11CCCh. 23.5 - Prob. 12CCCh. 23.5 - Prob. 13CCCh. 23.6 - Prob. 14CCCh. 23.6 - Prob. 15CCCh. 23.6 - Prob. 16CCCh. 23.6 - Prob. 17CCCh. 23 - Name the zones of the adrenal cortex and the...Ch. 23 - For (a) cortisol, (b) growth hormone, (c)...Ch. 23 - Prob. 3RQCh. 23 - Prob. 4RQCh. 23 - Define each of the following terms and explain its...Ch. 23 - Prob. 6RQCh. 23 - Prob. 7RQCh. 23 - Prob. 8RQCh. 23 - Define, compare, and contrast or relate the terms...Ch. 23 - Prob. 10RQCh. 23 - Prob. 11RQCh. 23 - Osteoclasts make acid (H+) from CO2 and H2O. They...Ch. 23 - Prob. 13RQCh. 23 - One diagnostic test to determine the cause of...Ch. 23 - Prob. 15RQCh. 23 - Prob. 16RQCh. 23 - Prob. 17RQCh. 23 - Prob. 18RQCh. 23 - Prob. 19RQ
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