Concepts of Genetics (12th Edition)
Concepts of Genetics (12th Edition)
12th Edition
ISBN: 9780134604718
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Chapter 23, Problem 17PDQ
Summary Introduction

To determine: The diagram that shows the important characteristics of the findings related to cell cycle remodeling.

Introduction: Checkpoints and the proliferation decision points regulate the progress of the cell through the cell cycle.

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A cell inherits a mutation in a gene that results in a transcription factor, called NF-kB, constantly being in its active conformation. When active, NF-kB stimulates the expression of cyclins that promote progression of the cell cycle, regardless of other conditions. As a result of this mutation, how would this cell's phenotype be affected by this mutation? A) This cell would have a cancer phenotype B) This cell would grow larger in size, but would never divide C) This cell would likely undergo apoptosis D) This cell would not duplicate its chromosomes .
There are several main model systems through which the first set of major breakthroughs in the understanding of cell cycle control was made.  Indicate whether each of the following statements is likely to be true or false for this initial phase of discovery.  The frog egg system was critical for developing genetic screens for identifying genes important for cell cycle regulation.      Cytoplasm extract from plant cells was used to identify factors important for cell cycle progression.       Temperature-sensitive mutants are critical for identifying genes essential for cell division.
To identify genes controlling the cell cycle in budding yeast, a genetic screen was carried out. In this screen, haploid yeast cells were exposed to a DNA damaging agent to introduce random mutations in the genome. By culturing cells at an elevated temperature (e.g. 37 degrees), where many mutated genes lose their function, scientists identified yeast mutants that showed growth defects and arrest at specific stages of the cell cycle (e.g. in mitosis with large buds). In this screen, mutants of the cyclin-dependent kinase were identified, but not mutants of cyclins. Explain the reason for this outcome.
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cell division of meiosis and mitosis; Author: Stated Clearly;https://www.youtube.com/watch?v=A-mFPZLLbHI;License: Standard youtube license