Concepts of Genetics (12th Edition)
12th Edition
ISBN: 9780134604718
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Chapter 23, Problem 2CS
Summary Introduction
To determine: The ethical details about the possible outcomes should be offered if the family member is found to carry the mutation and wish to continue with testing.
Introduction: The genomic analysis of a human identifies a single missense mutation of the transcription factor HOXD10. This mutation is the cause of two types of developmental malformations, and these are rocker bottom foot and claw foot.
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Here is a family pedigree for an imprinting disorder caused by a loss of function
mutation in a single imprinted gene. After generation I only related individuals are
shown. You can assume that the parents not included in the pedigree did not
carry the mutation.
%3D
II
IV
V
Male
O Female
Affected
Carrier
a) Does the mutation involve a gene that is normally expressed from the maternal
or from the paternal allele? Briefly explain your logic.
b) Identify two ways in which the pattern of inheritance shown in the pedigree is
different from X-linked inheritance
I.
Parthenogenesis has been documented in most vertebrate Classes (e.g. birds,
fish) but never in mammals. Genomic imprinting provides one explanation for this
observation. Why?
The following genotypes of two independently assorting autosomal genes determine coat color in rats:A-B- (gray); A-bb (yellow); aaB-(black); aabb (cream)A third gene pair on a separate autosome determines whetherany color will be produced. The CC and Cc genotypes allow coloraccording to the expression of the A and B alleles. However,the cc genotype results in albino rats regardless of the A and Balleles present. Determine the F1 phenotypic ratio of the followingcrosses: (a)AAbbCC * aaBBcc; (b) AaBBcc * AABbcc;(c) AaBbCc * AaBbcc.
In a woman who is a carrier of a mutant OTC deficiency allele, her sons who receive the mutant allele will be affected and her daughters will be carriers who may or may not be symptomatic, depending on random X inactivation in the liver.
1) Is this a single gene inheritance or multifactorial disease?
2) Is there a strong genetic or environmental cause to the development of this disease? If both genetic and environmental causes are implicated, you have to indicate each of them separately.
Chapter 23 Solutions
Concepts of Genetics (12th Edition)
Ch. 23 - Suppose you initiate a screen for maternal-effect...Ch. 23 - Prob. 2NSTCh. 23 - Prob. 1CSCh. 23 - Prob. 2CSCh. 23 - Prob. 1PDQCh. 23 - Prob. 2PDQCh. 23 - Prob. 3PDQCh. 23 - Nuclei from almost any source may be injected into...Ch. 23 - Distinguish between the syncytial blastoderm stage...Ch. 23 - Prob. 6PDQ
Ch. 23 - Prob. 7PDQCh. 23 - List the main classes of zygotic genes. What is...Ch. 23 - Experiments have shown that any nuclei placed in...Ch. 23 - Prob. 10PDQCh. 23 - Prob. 11PDQCh. 23 - Prob. 12PDQCh. 23 - Prob. 13PDQCh. 23 - Prob. 14PDQCh. 23 - Prob. 15PDQCh. 23 - Prob. 16PDQCh. 23 - Prob. 17PDQCh. 23 - A number of genes that control expression of Hox...Ch. 23 - The apterous gene in Drosophila encodes a protein...Ch. 23 - In Arabidopsis, flower development is controlled...Ch. 23 - Prob. 21ESPCh. 23 - Prob. 22ESPCh. 23 - Much of what we know about gene interactions in...Ch. 23 - Dominguez et al. (2004) suggest that by studying...
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