(a) Interpretation: The given carboxylic acids is to be prepared by using malonic ester synthesis. Concept introduction: The malonic ester synthesis is a method which is used to convert diethyl malonate into a carboxylic acid. NaOEt is a strong base. It abstracts a proton from the alpha carbon of an ester molecule to forms an enolate.

Question

Devise a synthesis of each compound from the given starting material(s). Albuterol is a bronchodilator and proparacaine is a local anesthetic.

Answer 1

Question

Chapter 23, Problem 23.44P

Interpretation Introduction

(a)

Interpretation: The given carboxylic acids is to be prepared by using malonic ester synthesis.

Concept introduction: The malonic ester synthesis is a method which is used to convert diethyl malonate into a carboxylic acid. NaOEt is a strong base. It abstracts a proton from the alpha carbon of an ester molecule to forms an enolate.

Interpretation Introduction

(b)

Interpretation: The given carboxylic acids are to be prepared by using malonic ester synthesis.

Concept introduction: The malonic ester synthesis is a method which is used to convert diethyl malonate into a carboxylic acid. NaOEt is a strong base. It abstracts a proton from the alpha carbon of an ester molecule to forms an enolate.

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Devise a synthesis of each compound from the given starting material(s). Albuterol is a bronchodilator and proparacaine is a local anesthetic.

Devise a synthesis of attached product from the given starting material. More than one step is required.

Devise a synthesis of attached product from the given starting material.More than one step is required.

Answer 2

Question

Chapter 23, Problem 23.44P

Interpretation Introduction

(a)

Interpretation: The given carboxylic acids is to be prepared by using malonic ester synthesis.

Concept introduction: The malonic ester synthesis is a method which is used to convert diethyl malonate into a carboxylic acid. NaOEt is a strong base. It abstracts a proton from the alpha carbon of an ester molecule to forms an enolate.

Interpretation Introduction

(b)

Interpretation: The given carboxylic acids are to be prepared by using malonic ester synthesis.

Concept introduction: The malonic ester synthesis is a method which is used to convert diethyl malonate into a carboxylic acid. NaOEt is a strong base. It abstracts a proton from the alpha carbon of an ester molecule to forms an enolate.

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Answer 3

Question

Chapter 23, Problem 23.44P

Interpretation Introduction

(a)

Interpretation: The given carboxylic acids is to be prepared by using malonic ester synthesis.

Concept introduction: The malonic ester synthesis is a method which is used to convert diethyl malonate into a carboxylic acid. NaOEt is a strong base. It abstracts a proton from the alpha carbon of an ester molecule to forms an enolate.

Interpretation Introduction

(b)

Interpretation: The given carboxylic acids are to be prepared by using malonic ester synthesis.

Concept introduction: The malonic ester synthesis is a method which is used to convert diethyl malonate into a carboxylic acid. NaOEt is a strong base. It abstracts a proton from the alpha carbon of an ester molecule to forms an enolate.

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Answer 4

Question

Chapter 23, Problem 23.44P

Interpretation Introduction

(a)

Interpretation: The given carboxylic acids is to be prepared by using malonic ester synthesis.

Concept introduction: The malonic ester synthesis is a method which is used to convert diethyl malonate into a carboxylic acid. NaOEt is a strong base. It abstracts a proton from the alpha carbon of an ester molecule to forms an enolate.

Interpretation Introduction

(b)

Interpretation: The given carboxylic acids are to be prepared by using malonic ester synthesis.

Concept introduction: The malonic ester synthesis is a method which is used to convert diethyl malonate into a carboxylic acid. NaOEt is a strong base. It abstracts a proton from the alpha carbon of an ester molecule to forms an enolate.

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Answer 5

Chapter 23, Problem 23.44P

Interpretation Introduction

(a)

Interpretation: The given carboxylic acids is to be prepared by using malonic ester synthesis.

Concept introduction: The malonic ester synthesis is a method which is used to convert diethyl malonate into a carboxylic acid. NaOEt is a strong base. It abstracts a proton from the alpha carbon of an ester molecule to forms an enolate.

Interpretation Introduction

(b)

Interpretation: The given carboxylic acids are to be prepared by using malonic ester synthesis.

Concept introduction: The malonic ester synthesis is a method which is used to convert diethyl malonate into a carboxylic acid. NaOEt is a strong base. It abstracts a proton from the alpha carbon of an ester molecule to forms an enolate.

Answer 6

Chapter 23, Problem 23.44P

Interpretation Introduction

(a)

Interpretation: The given carboxylic acids is to be prepared by using malonic ester synthesis.

Concept introduction: The malonic ester synthesis is a method which is used to convert diethyl malonate into a carboxylic acid. NaOEt is a strong base. It abstracts a proton from the alpha carbon of an ester molecule to forms an enolate.

Answer 7

Chapter 23, Problem 23.44P

Interpretation Introduction

(a)

Interpretation: The given carboxylic acids is to be prepared by using malonic ester synthesis.

Concept introduction: The malonic ester synthesis is a method which is used to convert diethyl malonate into a carboxylic acid. NaOEt is a strong base. It abstracts a proton from the alpha carbon of an ester molecule to forms an enolate.

Answer 8

Interpretation Introduction

(b)

Interpretation: The given carboxylic acids are to be prepared by using malonic ester synthesis.

Concept introduction: The malonic ester synthesis is a method which is used to convert diethyl malonate into a carboxylic acid. NaOEt is a strong base. It abstracts a proton from the alpha carbon of an ester molecule to forms an enolate.

Answer 9

Interpretation Introduction

(b)

Interpretation: The given carboxylic acids are to be prepared by using malonic ester synthesis.

Concept introduction: The malonic ester synthesis is a method which is used to convert diethyl malonate into a carboxylic acid. NaOEt is a strong base. It abstracts a proton from the alpha carbon of an ester molecule to forms an enolate.

Answer 10

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Answer 21

Ch. 23 - Problem 23.1 Draw the enol or keto tautomer(s) of...Ch. 23 - Prob. 23.2P Ch. 23 - Problem 23.3 When phenylacetaldehyde is dissolved...Ch. 23 - Prob. 23.4P Ch. 23 - Problem 23.5 Which bonds in the following...Ch. 23 - Prob. 23.6P Ch. 23 - Prob. 23.7P Ch. 23 - Prob. 23.8P Ch. 23 - Prob. 23.9P Ch. 23 - Prob. 23.10P

Solution Summary: The author explains how the carboxylic acid is prepared by using malonic ester synthesis.

Chapter 23 Solutions