(a) Interpretation: The intermediates A - C of the given stepwise conversion of p − isobutylbenzaldehyde to the analgesic ibuprofen are to be identified. Concept introduction: Ibuprofen is a synthetic compound which is widely used as a drug and as an analgesic and anti-inflammatory. It is synthesized from p − isobutylbenzaldehyde by using different reagents.

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Answer 1

Question

Chapter 23, Problem 23.54P

Interpretation Introduction

(a)

Interpretation: The intermediates A-C of the given stepwise conversion of p− isobutylbenzaldehyde to the analgesic ibuprofen are to be identified.

Concept introduction: Ibuprofen is a synthetic compound which is widely used as a drug and as an analgesic and anti-inflammatory. It is synthesized from p− isobutylbenzaldehyde by using different reagents.

Interpretation Introduction

(b)

Interpretation: The product formed by the direct alkylation of compound D by treatment with one equivalent of LDA and CH3I is to be identified and the reaction is to be explained.

Concept introduction: Ibuprofen is a synthetic compound which is widely used as a drug and as an analgesic and anti-inflammatory. It is synthesized from p− isobutylbenzaldehyde by using different reagents.

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Answer 2

Question

Chapter 23, Problem 23.54P

Interpretation Introduction

(a)

Interpretation: The intermediates A-C of the given stepwise conversion of p− isobutylbenzaldehyde to the analgesic ibuprofen are to be identified.

Concept introduction: Ibuprofen is a synthetic compound which is widely used as a drug and as an analgesic and anti-inflammatory. It is synthesized from p− isobutylbenzaldehyde by using different reagents.

Interpretation Introduction

(b)

Interpretation: The product formed by the direct alkylation of compound D by treatment with one equivalent of LDA and CH3I is to be identified and the reaction is to be explained.

Concept introduction: Ibuprofen is a synthetic compound which is widely used as a drug and as an analgesic and anti-inflammatory. It is synthesized from p− isobutylbenzaldehyde by using different reagents.

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Answer 3

Question

Chapter 23, Problem 23.54P

Interpretation Introduction

(a)

Interpretation: The intermediates A-C of the given stepwise conversion of p− isobutylbenzaldehyde to the analgesic ibuprofen are to be identified.

Concept introduction: Ibuprofen is a synthetic compound which is widely used as a drug and as an analgesic and anti-inflammatory. It is synthesized from p− isobutylbenzaldehyde by using different reagents.

Interpretation Introduction

(b)

Interpretation: The product formed by the direct alkylation of compound D by treatment with one equivalent of LDA and CH3I is to be identified and the reaction is to be explained.

Concept introduction: Ibuprofen is a synthetic compound which is widely used as a drug and as an analgesic and anti-inflammatory. It is synthesized from p− isobutylbenzaldehyde by using different reagents.

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Answer 4

Question

Chapter 23, Problem 23.54P

Interpretation Introduction

(a)

Interpretation: The intermediates A-C of the given stepwise conversion of p− isobutylbenzaldehyde to the analgesic ibuprofen are to be identified.

Concept introduction: Ibuprofen is a synthetic compound which is widely used as a drug and as an analgesic and anti-inflammatory. It is synthesized from p− isobutylbenzaldehyde by using different reagents.

Interpretation Introduction

(b)

Interpretation: The product formed by the direct alkylation of compound D by treatment with one equivalent of LDA and CH3I is to be identified and the reaction is to be explained.

Concept introduction: Ibuprofen is a synthetic compound which is widely used as a drug and as an analgesic and anti-inflammatory. It is synthesized from p− isobutylbenzaldehyde by using different reagents.

Expert Solution & Answer

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Answer 5

Chapter 23, Problem 23.54P

Interpretation Introduction

(a)

Interpretation: The intermediates A-C of the given stepwise conversion of p− isobutylbenzaldehyde to the analgesic ibuprofen are to be identified.

Concept introduction: Ibuprofen is a synthetic compound which is widely used as a drug and as an analgesic and anti-inflammatory. It is synthesized from p− isobutylbenzaldehyde by using different reagents.

Interpretation Introduction

(b)

Interpretation: The product formed by the direct alkylation of compound D by treatment with one equivalent of LDA and CH3I is to be identified and the reaction is to be explained.

Concept introduction: Ibuprofen is a synthetic compound which is widely used as a drug and as an analgesic and anti-inflammatory. It is synthesized from p− isobutylbenzaldehyde by using different reagents.

Answer 6

Chapter 23, Problem 23.54P

Interpretation Introduction

(a)

Interpretation: The intermediates A-C of the given stepwise conversion of p− isobutylbenzaldehyde to the analgesic ibuprofen are to be identified.

Concept introduction: Ibuprofen is a synthetic compound which is widely used as a drug and as an analgesic and anti-inflammatory. It is synthesized from p− isobutylbenzaldehyde by using different reagents.

Answer 7

Chapter 23, Problem 23.54P

Interpretation Introduction

(a)

Interpretation: The intermediates A-C of the given stepwise conversion of p− isobutylbenzaldehyde to the analgesic ibuprofen are to be identified.

Concept introduction: Ibuprofen is a synthetic compound which is widely used as a drug and as an analgesic and anti-inflammatory. It is synthesized from p− isobutylbenzaldehyde by using different reagents.

Answer 8

Interpretation Introduction

(b)

Interpretation: The product formed by the direct alkylation of compound D by treatment with one equivalent of LDA and CH3I is to be identified and the reaction is to be explained.

Concept introduction: Ibuprofen is a synthetic compound which is widely used as a drug and as an analgesic and anti-inflammatory. It is synthesized from p− isobutylbenzaldehyde by using different reagents.

Answer 9

Interpretation Introduction

(b)

Interpretation: The product formed by the direct alkylation of compound D by treatment with one equivalent of LDA and CH3I is to be identified and the reaction is to be explained.

Concept introduction: Ibuprofen is a synthetic compound which is widely used as a drug and as an analgesic and anti-inflammatory. It is synthesized from p− isobutylbenzaldehyde by using different reagents.

Answer 10

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Answer 11

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Answer 12

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Answer 13

Ch. 23 - Problem 23.1 Draw the enol or keto tautomer(s) of...Ch. 23 - Draw a stepwise mechanism for the following...Ch. 23 - Prob. 23.3P Ch. 23 - Prob. 23.4P Ch. 23 - Which CH bonds in the following molecules are...Ch. 23 - Prob. 23.6P Ch. 23 - Prob. 23.7P Ch. 23 - When ethyl acetoacetate (CH3COCH2CO2CH2CH3) is...Ch. 23 - Prob. 23.9P Ch. 23 - Prob. 23.10P

Solution Summary: The author explains the intermediates of the given stepwise conversion of p- isobutylbenzaldehyde to the analgesic ibuprofen.

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Chapter 23 Solutions