Concept explainers
(a)
To explain: The labelling pattern of the recovered deoxycytidylate residues if deoxycitidylate production in cell followed a pathway in which intact CDP is reduced to dCDP.
Concept introduction: Nucleotides are phosphate esters of a pentose in which a purine or pyrimidine base is linked to C1 of the sugar. Nucleotides are the building blocks of
(b)
To explain: The labelling pattern of the recovered deoxycytidylate residues if deoxycitidylate production in cell followed a pathway in which CDP is broken down to cytosine and ribose before reduction.
Concept introduction: Nucleotides are phosphate esters of a pentose in which a purine or pyrimidine base is linked to C1 of the sugar. Nucleotides are the building blocks of nucleic acid. Two pathways of nucleotide biosynthesis are de novo pathways and salvage pathways. First, ribonucleotides are produced, and then their corresponding deoxyribonucleotides are generated.
Want to see the full answer?
Check out a sample textbook solutionChapter 23 Solutions
FUNDAMENTALS OF BIOCHEMISTRY-ACCESS
- BiochemistryBiochemistryISBN:9781319114671Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.Publisher:W. H. FreemanLehninger Principles of BiochemistryBiochemistryISBN:9781464126116Author:David L. Nelson, Michael M. CoxPublisher:W. H. FreemanFundamentals of Biochemistry: Life at the Molecul...BiochemistryISBN:9781118918401Author:Donald Voet, Judith G. Voet, Charlotte W. PrattPublisher:WILEY
- BiochemistryBiochemistryISBN:9781305961135Author:Mary K. Campbell, Shawn O. Farrell, Owen M. McDougalPublisher:Cengage LearningBiochemistryBiochemistryISBN:9781305577206Author:Reginald H. Garrett, Charles M. GrishamPublisher:Cengage LearningFundamentals of General, Organic, and Biological ...BiochemistryISBN:9780134015187Author:John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. PetersonPublisher:PEARSON