A short essay to explain the molecular and cellular events leading to the heterozygotes individuals in sickle cell trait leading to the individual and population levels of biological organisation. . Introduction: Sickle cell disease is the most commonly occurring recessive inherited disorder found in African – Americans with an incidence of 1/400 and a carrier frequency of 1/10. It is caused due to the sickle cell allele that results in the structural and functional abnormality in normal haemoglobin. A point mutation that causes the substitution of glutamic acid by valine at 6 th position of β-globin chain of haemoglobin is the main cause. The homozygous recessive individuals suffer severely from the disease; however the heterozygous carriers have the benefit of killing the malarial parasites in malaria rich regions of the World.

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Chapter 23, Problem 8TYU

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To write: A short essay to explain the molecular and cellular events leading to the heterozygotes individuals in sickle cell trait leading to the individual and population levels of biological organisation. .

Introduction:

Sickle cell disease is the most commonly occurring recessive inherited disorder found in African – Americans with an incidence of 1/400 and a carrier frequency of 1/10. It is caused due to the sickle cell allele that results in the structural and functional abnormality in normal haemoglobin. A point mutation that causes the substitution of glutamic acid by valine at 6^th position of β-globin chain of haemoglobin is the main cause. The homozygous recessive individuals suffer severely from the disease; however the heterozygous carriers have the benefit of killing the malarial parasites in malaria rich regions of the World.

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