ORGANIC CHEMISTRY-WILEYPLUS ACCESS PKG.
12th Edition
ISBN: 9781119766919
Author: Solomons
Publisher: WILEY
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Question
Chapter 24, Problem 22P
Interpretation Introduction
Interpretation:
The amino acid sequence of bradykinin is to be determined.
Concept introduction:
A protein or peptide sequence is formed as a result of the peptide linkage between the amino acids. Further, different chemicals or enzyme may be used in order to decode the sequence of the amino acids, as the chemicals and the enzymes are only able to cleave the peptide sequenced at specific locations.
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Chapter 24 Solutions
ORGANIC CHEMISTRY-WILEYPLUS ACCESS PKG.
Ch. 24 - Prob. 1PPCh. 24 - Practice Problem 24.2 The guanidino group NHNHCNH2...Ch. 24 - Prob. 3PPCh. 24 - Prob. 4PPCh. 24 - Prob. 5PPCh. 24 - Prob. 6PPCh. 24 - Prob. 7PPCh. 24 - Practice Problem 24.8
Glutathione is a tripeptide...Ch. 24 - Prob. 9PPCh. 24 - Prob. 10PP
Ch. 24 - Prob. 11PPCh. 24 - Practice Problem 24.12 Show all steps in the...Ch. 24 - Practice Problem 24.13 The synthesis of a...Ch. 24 - Practice Problem 24.14
The terminal carboxyl...Ch. 24 - Prob. 15PPCh. 24 - Prob. 16PPCh. 24 - (a) Which amino acids in Table 24.1 have more than...Ch. 24 - Prob. 18PCh. 24 - 24.19 (a) On the basis of the following sequence...Ch. 24 - Prob. 20PCh. 24 - Prob. 21PCh. 24 - Prob. 22PCh. 24 - Prob. 23PCh. 24 - Prob. 24PCh. 24 - The enzyme lysozyme and its mechanism are...Ch. 24 - Prob. 2LGP
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- A chemically modified guanidino group is present in cimetidine (Tagamet), a widely prescribed drug for the control of gastric acidity and peptic ulcers. Cimetidine reduces gastric acid secretion by inhibiting the interaction of histamine with gastric H2 receptors. In the development of this drug, a cyano group was added to the substituted guanidino group to alter its basicity. Do you expect this modified guanidino group to be more basic or less basic than the guanidino group of arginine? Explain.arrow_forwardAn enzyme catalyzes the hydrolysis of an ester with a certain activity, but this activity is lost in a 3 M urea solution. What is the most likely explanation for the loss of activity? (A) Urea binds to the active site of the enzyme competitively with the substrate. (B) Urea causes the cleavage of the peptide bonds in the enzyme. (C) Urea causes the enzyme to denature and lose its specific three-dimensional shape. (D) Urea reacts with disulfide bonds in the enzyme.arrow_forwardBradykinin is a linear nonapeptide released by blood plasma globulin in response to a wasp sting. It is a very potent pain-causing agent. Its constituent amino acids are 2R, G, 2F, 3P, S. The sue of 2,4-dinitrofluorobenzene and carboxypeptidase shows that both terminal residues are arginine. Partial hydrolysis of bradykinin gives the following di- and tripeptides: FS + PGF +PP + SPF + FR + RParrow_forward
- R3 R1 R4 R2 Which chemical group is a hydrogen-bond acceptor that stabilizes an alpha-helical peptide? O C-O of the main chain O N-H of the main chain O hydroxyl group of side chain R2 O carboxyl group of side chain R2arrow_forwardIndicate whether each statement is true or false. (a) Tryptophan is an aromatic amino acid. (b) Lysine is positively charged at pH 7. (c) Asparagine has two amide bonds. (d) Isoleucine and leucine are enantiomers. (e) Valine is probably more water-soluble than arginine.arrow_forwardA chemically modified guanidino group is present in cimetidine (Tagamet), a widely prescribed drug for the control of gastric acidity and peptic ulcers. Cimetidine reduces gastric acid secretion by inhibiting the interaction of histamine with gastric H, recep- tors. In the development of this drug, a cyano group was added to the substituted gua- nidino group to alter its basicity. Do you expect this modified guanidino group to be more basic or less basic than the guanidino group of arginine? Explain. N-CN H,C CH,SCH,CH,NHËNHCH, HN, Cimetidine (Tagamet)arrow_forward
- The pKa values of alpha-amino group, carboxylic acid group and the sidechain group of arginine are 9.04, 2.17 and 12,48 respectively. What percentage of arginine molecules would be neutral in a solution of arginine at pH 13?arrow_forwardWhat fraction of the side-chain amine on arginine is protonated at pH=10? At pH = 13? Express as a %. At pH = 10, 0% protonated. At pH = 13,76% protonated. At pH=10, 100% protonated. At pH-13, 76% protonated. At pH= 10, 0% protonated. At pH=13, 24% protonated. At pH-10, 100% protonated. At pH= 13, 24% protonatedarrow_forwardDraw a titration curve for the following peptide and circle the region(s) where this peptide would be a good buffer. Label the location on the titration curve where the peptide is least soluble: H-A-I-Yarrow_forward
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