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Chemistry & Chemical Reactivity

10th Edition
John C. Kotz + 3 others
ISBN: 9781337399074

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BuyFindarrow_forward

Chemistry & Chemical Reactivity

10th Edition
John C. Kotz + 3 others
ISBN: 9781337399074
Textbook Problem

Kynamro has the hydrogen bonding sequence: GCCUCAGTCTGCTTCGCACC. What is the sequence of nucleotides in the targeted mRNA?

Interpretation Introduction

Interpretation:

The sequence of nucleotide in a targeted mRNA. The hydrogen bondong seqeunce of Kynamro is GCCUCAGTCTGCTTCGCACC has to be identified.

Concept introduction: The drug call ‘Kynamro’ targets the mRNA for protein involved in a rare condition that lead to very high level of cholestreol called homozygous familial hypercholestreolemia.

Kynamro has the backbone that contain phosphorothioate group in which oxygen attached to phosphorous is replaced by sulphur atom.(Refer fig 24.1).

A purine base Adenine (A) always pair with pyrimidine base Uracil (U) and the pyrimidine base Cytosine (C) always pair with purine base Guanine (G).

Explanation

From the DNA sequence the mRNA sequence is determined. Sequence of mRNA is divided into groups of three nucleotides (Refer table 24.1). A purine base Adenine (A) always pair with pyrimidine base Uracil (U) and the pyrimidine base Cytosine (C) always pair with purine base Guanine (G)

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