EBK BIOLOGY
11th Edition
ISBN: 8220102797352
Author: Raven
Publisher: YUZU
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Chapter 25, Problem 1S
The paired-like homeodomain transcription factor 1 (pitxl) is expressed in the hindlimbs of developing mouse embryos, and its homologue is expressed in the pelvic region of the nine-spine stickleback fish (Pungitius pungitius). You are beginning a research project on pitxl and your supervisor is convinced that pitxl has been co-opted to make armor around the pelvic region of this species of stickleback. You begin by isolating RNA from a freshwater Pungitius pungitius that has very reduced armor. You convert the RNA to cDNA and amplify the pitxl cDNA using PCR. You have your pitxl PCR product sequenced and find it has exactly the same sequence as the marine Pungitius pungitius with armor. In light of this evidence, analyze your supervisor's hypothesis.
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Mutation in the fibroblast growth factor receptor (FGFR) gene results in achondroplasia (dwarfism), which is a dominant condition caused by a single base substitution (GGG>AGG) that changes the amino acid glycine at position 480 to arginine (G480R) in the FGFR protein. FGFR is normally active when FGF binds to it, but the mutant FGFR is always on to stimulate signaling that inhibits excessive bone growth.
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Mutation in the fibroblast growth factor receptor (FGFR) gene results in achondroplasia (dwarfism), which is a
dominant condition caused by a single base substitution (GGG>AGG) that changes the amino acid glycine at
position 480 to arginine (G480R) in the FGFR protein. Normally, FGFR is active when FGF binds to it and
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OPronuclear injection of a mutant copy (G48OR) of the gene to a mouse zygote
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O CRISPR that knocks out the wild-type gene in a mouse genome
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Chapter 25 Solutions
EBK BIOLOGY
Ch. 25 - Heterochrony is a. the alteration of the spatial...Ch. 25 - Vast differences in the phenotypes of organisms as...Ch. 25 - Homoplastic structures a can Involve convergence...Ch. 25 - Hox genes are a. found in both plants and animals....Ch. 25 - The Brachyury and Thx5 in vertebrates and the Ap3...Ch. 25 - Which of the following statements about Pax6 is...Ch. 25 - Which of the following statements about TbxS is...Ch. 25 - Prob. 8UCh. 25 - Transcription factors are a. genes. b. sequences...Ch. 25 - Independently derived mutations of the CTC gene in...
Ch. 25 - Prob. 1ACh. 25 - Prob. 2ACh. 25 - The Eda allele that causes reduced armor...Ch. 25 - Prob. 4ACh. 25 - The paired-like homeodomain transcription factor 1...Ch. 25 - From the chapter on evolution of development it...Ch. 25 - Phenotypic diversity among major groups of...Ch. 25 - Critique the argument that eyes have multiple...Ch. 25 - Prob. 5SCh. 25 - Having read all of this chapter return to the clam...
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