Biochemistry: Concepts and Connections (2nd Edition)
Biochemistry: Concepts and Connections (2nd Edition)
2nd Edition
ISBN: 9780134641621
Author: Dean R. Appling, Spencer J. Anthony-Cahill, Christopher K. Mathews
Publisher: PEARSON
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Chapter 25, Problem 25P
Interpretation Introduction

Interpretation:

Mutation on tRNA converting trp into nonsense anti codon should be identified.

Concept introduction:

Substitution mutation is a single base mutation, in which a single base is substituted to cause mutation known as point mutation. Some mutation may result in the production of stop codon which terminates the chain and thus is known as nonsense mutation.

Tryptophan is denoted by trp and is coded by triplet of three bases UGG in which substitution of a single base is occurred to cause mutation such as middle base guanine get substituted by adenine to produce a stop codon UAG which terminates the amino acid chain.

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Mitochondrial mutations; Author: Useful Genetics;https://www.youtube.com/watch?v=GvgXe-3RJeU;License: CC-BY