Using prostaglandin, the glaucoma drug bimatoprost is synthesized in two steps. A method for this conversion is to be suggested. Concept introduction: The amide can be prepared by the nucleophilic substitution of acyl chloride by the amine. Two moles amines used with one mole of acyl chloride, because one amine molecule acts as a nucleophile and the second acts as a Brønsted base. The carboxylic acids on reaction with thionyl chloride forms acyl chloride by replacing the hydroxyl group of the carboxylic acid with chlorine atom.

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Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 25, Problem 32P

Interpretation Introduction

Interpretation:

Using prostaglandin, the glaucoma drug bimatoprost is synthesized in two steps. A method for this conversion is to be suggested.

Concept introduction:

The amide can be prepared by the nucleophilic substitution of acyl chloride by the amine.

Two moles amines used with one mole of acyl chloride, because one amine molecule acts as a nucleophile and the second acts as a Brønsted base.

The carboxylic acids on reaction with thionyl chloride forms acyl chloride by replacing the hydroxyl group of the carboxylic acid with chlorine atom.

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Answer 2

Question

Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 25, Problem 32P

Interpretation Introduction

Interpretation:

Using prostaglandin, the glaucoma drug bimatoprost is synthesized in two steps. A method for this conversion is to be suggested.

Concept introduction:

The amide can be prepared by the nucleophilic substitution of acyl chloride by the amine.

Two moles amines used with one mole of acyl chloride, because one amine molecule acts as a nucleophile and the second acts as a Brønsted base.

The carboxylic acids on reaction with thionyl chloride forms acyl chloride by replacing the hydroxyl group of the carboxylic acid with chlorine atom.

Expert Solution & Answer

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Answer 3

Question

Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 25, Problem 32P

Interpretation Introduction

Interpretation:

Using prostaglandin, the glaucoma drug bimatoprost is synthesized in two steps. A method for this conversion is to be suggested.

Concept introduction:

The amide can be prepared by the nucleophilic substitution of acyl chloride by the amine.

Two moles amines used with one mole of acyl chloride, because one amine molecule acts as a nucleophile and the second acts as a Brønsted base.

The carboxylic acids on reaction with thionyl chloride forms acyl chloride by replacing the hydroxyl group of the carboxylic acid with chlorine atom.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 4

Question

Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 25, Problem 32P

Interpretation Introduction