(a) To determine: A Graph between allosteric v vs. aspartate curve for ATCase in the absence of effector is to be plotted Concept Introduction : The first step in the pyrimidine biosynthetic pathway is catalyzed by Aspartate carbamoyltransferase. There are 12 subunits present in the multi-subunit protein complex enzyme in E.coli .

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Answer 1

Question

Chapter 26, Problem 12P

Interpretation Introduction

(a)

To determine:

A Graph between allosteric v vs. aspartate curve for ATCase in the absence of effector is to be plotted

Concept Introduction :

The first step in the pyrimidine biosynthetic pathway is catalyzed by Aspartate carbamoyltransferase. There are 12 subunits present in the multi-subunit protein complex enzyme in E.coli .

Interpretation Introduction

(b)

To determine:

A Graph between allosteric v vs. aspartate curve for ATCase in the presence of activator is to be plotted.

Concept Introduction :

The first step in the pyrimidine biosynthetic pathway is catalyzed by Aspartate carbamoyltransferase. There are 12 subunits present in the multi-subunit protein complex enzyme in E.coli .

Interpretation Introduction

(c)

To determine:

A Graph between allosteric v vs. aspartate curve for ATCase in presence of inhibitor is to be plotted.

Concept Introduction :

The first step in the pyrimidine biosynthetic pathway is catalyzed by Aspartate carbamoyltransferase. There are 12 subunits present in the multi-subunit protein complex enzyme in E.coli .

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Phosphonacetyl-L-aspartate (PALA) is a potent inhibitor of aspartate transcarbamoylase because itmimics the two physiological substrates of the enzyme. However, in the presence of substrates, lowconcentrations of PALA increase the reaction rate of aspartate transcarbamoylase. Explain this result.

The reaction catalyzed by phosphorylase is readily reversible in vitro. At pH 6.8, the equilibrium ratio of orthophosphate to glucose 1-phosphate is 3.6. The value of ΔG°’ for this reaction is small because a glycosidic bond is replaced by a phosphoryl ester bond that has a nearly equal transfer potential. However, phosphorolysis proceeds far in the direction of glycogen breakdown in vivo. Suggest one means by which the reaction can be made irreversible in vivo.

The regulation of Glutamine Synthetase (GS) in E.coli, a model for this highly conserved homodecamer in mammals, and is a striking example of cumulative feedback inhibition through allosteric regulation. Explain the cumulative feedback inhibition of GS..

Answer 2

Question

Chapter 26, Problem 12P

Interpretation Introduction

(a)

To determine:

A Graph between allosteric v vs. aspartate curve for ATCase in the absence of effector is to be plotted

Concept Introduction :

The first step in the pyrimidine biosynthetic pathway is catalyzed by Aspartate carbamoyltransferase. There are 12 subunits present in the multi-subunit protein complex enzyme in E.coli .

Interpretation Introduction

(b)

To determine:

A Graph between allosteric v vs. aspartate curve for ATCase in the presence of activator is to be plotted.

Concept Introduction :

The first step in the pyrimidine biosynthetic pathway is catalyzed by Aspartate carbamoyltransferase. There are 12 subunits present in the multi-subunit protein complex enzyme in E.coli .

Interpretation Introduction

(c)

To determine:

A Graph between allosteric v vs. aspartate curve for ATCase in presence of inhibitor is to be plotted.

Concept Introduction :

The first step in the pyrimidine biosynthetic pathway is catalyzed by Aspartate carbamoyltransferase. There are 12 subunits present in the multi-subunit protein complex enzyme in E.coli .

Expert Solution & Answer

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Check out a sample textbook solution

See solution

Answer 3

Question

Chapter 26, Problem 12P

Interpretation Introduction

(a)

To determine:

A Graph between allosteric v vs. aspartate curve for ATCase in the absence of effector is to be plotted

Concept Introduction :

The first step in the pyrimidine biosynthetic pathway is catalyzed by Aspartate carbamoyltransferase. There are 12 subunits present in the multi-subunit protein complex enzyme in E.coli .

Interpretation Introduction

(b)

To determine:

A Graph between allosteric v vs. aspartate curve for ATCase in the presence of activator is to be plotted.

Concept Introduction :

The first step in the pyrimidine biosynthetic pathway is catalyzed by Aspartate carbamoyltransferase. There are 12 subunits present in the multi-subunit protein complex enzyme in E.coli .

Interpretation Introduction

(c)

To determine:

A Graph between allosteric v vs. aspartate curve for ATCase in presence of inhibitor is to be plotted.

Concept Introduction :

The first step in the pyrimidine biosynthetic pathway is catalyzed by Aspartate carbamoyltransferase. There are 12 subunits present in the multi-subunit protein complex enzyme in E.coli .

Expert Solution & Answer

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Check out a sample textbook solution

See solution

Answer 4

Question

Chapter 26, Problem 12P

Interpretation Introduction

(a)

To determine:

A Graph between allosteric v vs. aspartate curve for ATCase in the absence of effector is to be plotted

Concept Introduction :

The first step in the pyrimidine biosynthetic pathway is catalyzed by Aspartate carbamoyltransferase. There are 12 subunits present in the multi-subunit protein complex enzyme in E.coli .

Interpretation Introduction

(b)

To determine:

A Graph between allosteric v vs. aspartate curve for ATCase in the presence of activator is to be plotted.

Concept Introduction :

The first step in the pyrimidine biosynthetic pathway is catalyzed by Aspartate carbamoyltransferase. There are 12 subunits present in the multi-subunit protein complex enzyme in E.coli .

Interpretation Introduction

(c)

To determine:

A Graph between allosteric v vs. aspartate curve for ATCase in presence of inhibitor is to be plotted.

Concept Introduction :

The first step in the pyrimidine biosynthetic pathway is catalyzed by Aspartate carbamoyltransferase. There are 12 subunits present in the multi-subunit protein complex enzyme in E.coli .

Expert Solution & Answer

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Check out a sample textbook solution

See solution

Answer 5

Chapter 26, Problem 12P

Interpretation Introduction

(a)

To determine:

A Graph between allosteric v vs. aspartate curve for ATCase in the absence of effector is to be plotted

Concept Introduction :

The first step in the pyrimidine biosynthetic pathway is catalyzed by Aspartate carbamoyltransferase. There are 12 subunits present in the multi-subunit protein complex enzyme in E.coli .

Interpretation Introduction

(b)

To determine:

A Graph between allosteric v vs. aspartate curve for ATCase in the presence of activator is to be plotted.

Concept Introduction :

The first step in the pyrimidine biosynthetic pathway is catalyzed by Aspartate carbamoyltransferase. There are 12 subunits present in the multi-subunit protein complex enzyme in E.coli .

Interpretation Introduction

(c)

To determine:

A Graph between allosteric v vs. aspartate curve for ATCase in presence of inhibitor is to be plotted.

Concept Introduction :

The first step in the pyrimidine biosynthetic pathway is catalyzed by Aspartate carbamoyltransferase. There are 12 subunits present in the multi-subunit protein complex enzyme in E.coli .

Answer 6

Chapter 26, Problem 12P

Interpretation Introduction

(a)

To determine:

A Graph between allosteric v vs. aspartate curve for ATCase in the absence of effector is to be plotted

Concept Introduction :

The first step in the pyrimidine biosynthetic pathway is catalyzed by Aspartate carbamoyltransferase. There are 12 subunits present in the multi-subunit protein complex enzyme in E.coli .

Answer 7

Chapter 26, Problem 12P

Interpretation Introduction

(a)

To determine:

A Graph between allosteric v vs. aspartate curve for ATCase in the absence of effector is to be plotted

Concept Introduction :

The first step in the pyrimidine biosynthetic pathway is catalyzed by Aspartate carbamoyltransferase. There are 12 subunits present in the multi-subunit protein complex enzyme in E.coli .

Answer 8

Interpretation Introduction

(b)

To determine:

A Graph between allosteric v vs. aspartate curve for ATCase in the presence of activator is to be plotted.

Concept Introduction :

The first step in the pyrimidine biosynthetic pathway is catalyzed by Aspartate carbamoyltransferase. There are 12 subunits present in the multi-subunit protein complex enzyme in E.coli .

Answer 9

Interpretation Introduction

(b)

To determine:

A Graph between allosteric v vs. aspartate curve for ATCase in the presence of activator is to be plotted.

Concept Introduction :

The first step in the pyrimidine biosynthetic pathway is catalyzed by Aspartate carbamoyltransferase. There are 12 subunits present in the multi-subunit protein complex enzyme in E.coli .

Answer 10

Interpretation Introduction

(c)

To determine:

A Graph between allosteric v vs. aspartate curve for ATCase in presence of inhibitor is to be plotted.

Concept Introduction :

The first step in the pyrimidine biosynthetic pathway is catalyzed by Aspartate carbamoyltransferase. There are 12 subunits present in the multi-subunit protein complex enzyme in E.coli .

Answer 11

Interpretation Introduction

(c)

To determine:

A Graph between allosteric v vs. aspartate curve for ATCase in presence of inhibitor is to be plotted.

Concept Introduction :

The first step in the pyrimidine biosynthetic pathway is catalyzed by Aspartate carbamoyltransferase. There are 12 subunits present in the multi-subunit protein complex enzyme in E.coli .

Answer 12

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Answer 13

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Answer 14

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Answer 15

Ch. 26 - Prob. 1P Ch. 26 - Prob. 2P Ch. 26 - Allosteric Regulation of Purine and Pyrimidine...Ch. 26 - Inhibition of Purine and Pyrimidine Metabolism by...Ch. 26 - Prob. 5P Ch. 26 - Allosteric Regulation of Ribonucleotide Reductase...Ch. 26 - Prob. 7P Ch. 26 - Prob. 8P Ch. 26 - Prob. 9P Ch. 26 - Prob. 10P

Solution Summary: The author explains how the first step in the pyrimidine biosynthetic pathway is catalyzed by Aspartate carbamoyltransferase.

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