Concept explainers
Interpretation:
An explanation corresponding to the fact that the automated amino acid analysis of peptides that contain asparagine
Concept introduction:
The amino acids are the organic compounds in which the functional groups present are:
Amino acids consist of both positive as well negative groups in their structure and are called as ampholytes.
The small chain of amino acids that is connected with the help of the amide bonds is known as peptide.
A peptide possesses the covalent bonds which are formed by the reaction of carboxyl group present in one amino acid with the amino group present in other amino acid.
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ORGANIC CHEMISTRY,VOL.1 >CUSTOM<
- Show by a series of equations (with structures) the first stage of the Edman method applied to a peptide that has leucine as its N-terminal residue.arrow_forwardGiven the following peptide SEPIMAPVEYPK(a) Estimate the net charge at pH 7 and at pH 12. Assume the pKa valuesgiven in as shown. (b) How many peptides would result if this peptide were treated with(1) cyanogen bromide, (2) trypsin, or (3) chymotrypsin?(c) Suggest a method for separating the peptides produced by chymotrypsintreatment.arrow_forwardWhich of the following is an acceptable name for the peptide sequence below?arrow_forward
- In a paragraph form provide the experimental procedure of the reaction of oxazetidine-containing peptides and α-ketoacid that will result in protein that contain native serine residuesarrow_forward1, on derivative curves, there are several sharp peaks. what points in the ionisation of the amino acid do these peaks represent? 2. what is the relationship between equivalence points and the PKA of each ionisable groupsarrow_forwardThe -helical parts of myoglobin and other proteins stop whenever a proline residue is encountered in the chain. Why is proline never present in a protein helix?arrow_forward
- Give the sequence of the following tetrapeptide:arrow_forwardAccording to the paper, F486 is a phenylalanine residue (i.e., an amino acid that is part of a chain that forms a protein) on SARS-CoV-2. It has an important interaction with ACE2 (best seen in Fig. 1(C) and Fig. 2(A)). Looking at this phenylalanine and the green residues surrounding it, which statement best describes the interaction that could be occurring? a) It forms a hydrogen bond with Y83. b) It forms a dipole-dipole interaction with M82. c) It forms London dispersion forces with surrounding residues. d) It encounters repulsions from surrounding residues.arrow_forwardPyMol commands needed to make the following image of a helix (residues 84-104) found in the Ras protein (PDB code - 1Q21). There is a distinctive "kink" in the alpha helix which occurs at residue Asp-92, the side chain for this residue is shown and colored by atom.arrow_forward
- Based on the given figure,a. what is the possible identity of the amino acid?b. what is the isoelectric point of AAc. what is the pKa corresponding to the dissociation of alpha carboxylic groupd. where is the region or point where AA is predominantly present as a (-2) charged speciese. where is the effective buffering range for the amino acid on the acidic regionarrow_forward1a. suggest a test you will use to show that a given food substance contains protein. b. show how you will use i. modified Gabriels synthesis ii. Streckers synthesis to prepare phenylalanine in the laboratory. 2a. Describe in details how you will determine the primary structure of protein. b. You have been given a mixture of lysine, histidine and cysteine. The isoelectric point of the amino acids are as follows, Histidine 7.64 Lysine 9.74 Cysteine 5.02 Show how you will separate the mixture into the pure forms. State and describe any instrument that you will use to separate the components. 3a. A decapeptide has the following amino acid composition, Ala2, Arg, Cys, Glu, Gly, Leu, Lys, Phe, Val Partial hydrolysis yields the following tripeptides, Cys-Glu-Leu +Gly-Arg-Ala +Lys-Val-Phe-Gly Reaction of the decapeptide with 2,4-dinitrofluorobenzene yields 2,4-dinitrophenylsine. From the experimental data, deduce the primary structure of the…arrow_forwardConsider the peptide EAHIVR. Write out the sequence of the peptide from N to C in three letter code. Draw the complete structure of the peptide including all peptide bonds and side chains at pH 8.0. Calculate the pI of this peptide. Calculate the net charge of this peptide at pH 2, pH 7, and pH 11. *please show math for # 3 and #4 pls*arrow_forward
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