ORGANIC CHEMISTRY-W/ACCESS >CUSTOM<
ORGANIC CHEMISTRY-W/ACCESS >CUSTOM<
10th Edition
ISBN: 9781260028362
Author: Carey
Publisher: MCG CUSTOM
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Chapter 26, Problem 36P
Interpretation Introduction

Interpretation:

An explanation corresponding to the fact that the automated amino acid analysis of peptides that contain asparagine (Asn) and glutamine (Gln) residues gives a peak corresponding to ammonia is to be stated.

Concept introduction:

The amino acids are the organic compounds in which the functional groups present are: amine (-NH2) functional group, carboxyl (-COOH) functional group and a side chain (-R).

Amino acids consist of both positive as well negative groups in their structure and are called as ampholytes.

The small chain of amino acids that is connected with the help of the amide bonds is known as peptide.

A peptide possesses the covalent bonds which are formed by the reaction of carboxyl group present in one amino acid with the amino group present in other amino acid.

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Why is glycine the only amino acid commonly observed in peptides inconformations with phi and psi values which are not restricted to the values in the Ramachandran plot below?
Consider the partial sequence of a peptide.I L W A N R M S H V L F A V E ASelect all amino acid residues likely to be on the solvent‑exposed surface once the peptide folds into its native conformation.
Given the following peptideSEPIMAPVEYPK(a) Estimate the net charge at pH 7 and at pH 12. Assume the pKa valuesgiven in Table                                                                                                    (b) How many peptides would result if this peptide were treated with(1) cyanogen bromide, (2) trypsin, or (3) chymotrypsin?(c) Suggest a method for separating the peptides produced by chymotrypsintreatment.
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