Concept explainers
Interpretation:
The reasonphage λ would need to synthesize more cI repressor during establishment of lysogeny, early in infection, rather than in maintenance of the lysogenic state.
Concept introduction:
In lysogeny infection, phage λ DNA integrates into the host genome and retains for many thousands generation until viral chromosome gets excised from host genome and a lytic cycle begins. Double stranded phage λ DNA contains 50 genes that are transcribed using host RNA polymerase and are assembled to form virions followed by lyses of host cell.
In the early stages of lysogeny, the ORIII site is unbound and cI actively gets synthesized and when cI is in high concentration i.e. during maintenance of lysogeny, it gets bound to ORIII,repressing the PRMpromoter and cI synthesis decreases.
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