ORGANIC CHEMISTRY-W/STUD.SOLN.MAN.
10th Edition
ISBN: 9781260001099
Author: Carey
Publisher: MCG
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Question
Chapter 26.12, Problem 20P
Interpretation Introduction
Interpretation:
The structure of the PTH derivative isolated in the second Edman cycle of the tetrapeptide
Concept Introduction:
Edman degradation uses phenyl isothiocyanate to cleave the bond between the N-terminal amino acid and the rest of the peptide chain.
Anhydrous conditions ensure that other amide bonds are not cleaved.
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Hemoglobin A has a pI value of 5.6 whereas the variant hemoglobin M has an aspartate residue in place of the normal valine at position 85 of the alpha chain. What effect will this substitution have on the electrophoretic behavior of the protein at pH 7.0. (explain clearly the reason for your answer)
1. Taking the structure of the amino acids into account, give a comparative discussion pK values where histidine=2 and alanine=2.
Explain why the pI of lysine is the average of the pKa values of its two protonated amino groups.
Chapter 26 Solutions
ORGANIC CHEMISTRY-W/STUD.SOLN.MAN.
Ch. 26.1 - Prob. 1PCh. 26.2 - Prob. 2PCh. 26.2 - Prob. 3PCh. 26.3 - Prob. 4PCh. 26.3 - Prob. 5PCh. 26.4 - Prob. 6PCh. 26.4 - Prob. 7PCh. 26.4 - Prob. 8PCh. 26.5 - Prob. 9PCh. 26.6 - Prob. 10P
Ch. 26.6 - Prob. 11PCh. 26.6 - Prob. 12PCh. 26.7 - Prob. 13PCh. 26.7 - Prob. 14PCh. 26.7 - Prob. 15PCh. 26.7 - Prob. 16PCh. 26.7 - Prob. 17PCh. 26.9 - Prob. 18PCh. 26.10 - Digestion of the tetrapeptide of Problem 26.18...Ch. 26.12 - Prob. 20PCh. 26.12 - Prob. 21PCh. 26.15 - Prob. 22PCh. 26.15 - Prob. 23PCh. 26.16 - Prob. 24PCh. 26.17 - Prob. 25PCh. 26.18 - Prob. 26PCh. 26 - Prob. 27PCh. 26 - Prob. 28PCh. 26 - Prob. 29PCh. 26 - Prob. 30PCh. 26 - Prob. 31PCh. 26 - Prob. 32PCh. 26 - Prob. 33PCh. 26 - Prob. 34PCh. 26 - Prob. 35PCh. 26 - Prob. 36PCh. 26 - Prob. 37PCh. 26 - Prob. 38PCh. 26 - Prob. 39PCh. 26 - Prob. 40PCh. 26 - If you synthesized the tripeptide Leu-Phe-Ser from...Ch. 26 - Prob. 42PCh. 26 - Prob. 43PCh. 26 - Prob. 44PCh. 26 - Prob. 45DSPCh. 26 - Prob. 46DSPCh. 26 - Prob. 47DSPCh. 26 - Prob. 48DSPCh. 26 - Prob. 49DSPCh. 26 - Prob. 50DSP
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.Similar questions
- Given: Alanine: pKa=4 Pkb=9 Histidine: pKa=2 pKb=6 and pKc=9 Taking the structure of the amino acids into account, give a comparative discussion of these pK values.arrow_forwardShow the condensation reactions that result in the formation of the tetrapeptide Asp-Gly-Ser- Gln. After you have finished the synthesis change the structure to show how it would exist in a cell at physiological pH (pH = 7).arrow_forwardHis-Met-Asp-Tyr-Phe-Ser Calculate an approximate pI (isoelectric point) for this peptide.arrow_forward
- If the pH of a solution of Arginine is equal to a half of the 3 pka values of all of its functional groups, what will be the charge on the majority of the Arg molecules in that solution? Please explain. Am i supposedd to add up the three pka values and then divide it in half to find the pH? Thanksarrow_forwardProvide the structure of Thr-Gln-Met.arrow_forwardOne of the levels of proteins is called tertiary. Name and define two of the categories for tertiary BESIDES hydrogen bonds.arrow_forward
- If you had a protein X, which is a soluble enzyme found inside the peroxisome, and you wished to separate it from a similar protein Y, which is an enzyme found embedded in the mitochondrial membrane, what would be your initial techniques for isolating these proteins?arrow_forwardWhich has a higher percentage of negative charge at physiological pH (7.4), leucine with pI = 5.98 or asparagine with pI = 5.43?arrow_forward99. The _____________ plot shows the free energy change for a given amino acid window, allowing the prediction of transmembrane helices.arrow_forward
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