Brock Biology of Microorganisms
15th Edition
ISBN: 9780134626352
Author: MADIGAN
Publisher: PEARSON
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Chapter 27, Problem 4AQ
What problems would arise if a person had a hereditary deficiency that resulted in an inability to present antigens to Tc cells? What would the problems be if the person had a deficiency in presenting antigen to Th1 cells? To Th2 cells? To all T cells? What molecules might be deficient in each situation? Could a person having any one of these deficiencies survive in a normal environment? Explain for each.
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Which of the following statements regarding T cells activated by specific antigen is incorrect?
a. They receive co-stimulatory signals through CD28.
b. They suppress expression of sphingosine 1-phosphate (SIP).
c. They take several days before differentiating into effector T cells.
d. They cease to secrete and respond to interleukin-2 (IL-2).
e. They begin to express CTLA4, which serves to limit T-cell proliferation.
If you were missing the gene sequence that codes for CD3, what consequence would this have on T cells? How would it effect maturation, activation, and differentiation?
All of the following are characteristic of regulatory T cells except
a. they express CD25
b. they facilitate the proliferation of naive T cells interacting with the same antigen-presenting cell
c. they express CD4
d. they express the transcriptional repressor FoxP3
e. they express MHC class II-restricted T-cell receptors specific for self antigen.
Chapter 27 Solutions
Brock Biology of Microorganisms
Ch. 27.1 - Prob. 1MQCh. 27.1 - Prob. 2MQCh. 27.1 - Distinguish between clonal deletion and clonal...Ch. 27.1 - QWhy is it necessary that all three defining...Ch. 27.2 - Identify the intrinsic and extrinsic properties of...Ch. 27.2 - Describe an epitope recognized by an antibody, and...Ch. 27.2 - Give an example for each: natural and artificial...Ch. 27.2 - QWhat properties are required for a vaccine to...Ch. 27.3 - Summarize antibody production starting with...Ch. 27.3 - Differentiate among antibody classes using...
Ch. 27.3 - Prob. 3MQCh. 27.3 - QDescribe the structural and functional...Ch. 27.4 - Draw a complete Ig molecule and identify...Ch. 27.4 - Describe antigen binding to the CDR1, 2, and 3...Ch. 27.4 - Describe the recombination events that produce a...Ch. 27.4 - QWhich Ig chains are used to construct a complete...Ch. 27.5 - Identify the cells that display MHC class I and...Ch. 27.5 - Compare the MHC I and MHC II protein structures...Ch. 27.5 - Define the sequence of events for processing and...Ch. 27.5 - QDescribe the basic structure of class I and class...Ch. 27.6 - Define polymorphism and polygeny as they apply to...Ch. 27.6 - How does a single MHC protein present many...Ch. 27.6 - QPolymorphism implies that each different MHC...Ch. 27.7 - Prob. 1MQCh. 27.7 - Identify diversity-generating mechanisms unique to...Ch. 27.7 - Describe and compare the structural features of Ig...Ch. 27.7 - QWhat diversity-generating mechanisms function to...Ch. 27.8 - Describe the mechanism used by Tc cells to...Ch. 27.8 - Describe the effector system (the cell-killing...Ch. 27.8 - Compare and contrast the roles and activities of...Ch. 27.8 - QWhat mechanism do Tc cells use to identify and...Ch. 27.9 - Discriminate between immediate hypersensitivity...Ch. 27.9 - Provide examples and mechanisms for an...Ch. 27.9 - QHow do immediate and delayed-type...Ch. 27.10 - Describe the binding site for superantigens on T...Ch. 27.10 - Compare and contrast the immunodeficiency observed...Ch. 27.10 - Prob. 3MQCh. 27.10 - Prob. 1CRCh. 27 - Antibodies of the IgA class are probably more...Ch. 27 - Prob. 2AQCh. 27 - Polymorphism implies that each different MHC...Ch. 27 - What problems would arise if a person had a...
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- Which type of T cell is most effective against viruses? Th1 Th2 cytotoxic T cells regulatory T cellsarrow_forwardWhat is the difference between a T-cell-dependent and T-cell- independent response?arrow_forwardIf a given B cell produces only one type of antibody, how do organisms produce a great diversity of antibodies?arrow_forward
- Generally speaking, what kinds of cells express MHC I, MHC II, or both? What is presented on MHC I and II, and what kind of T cell recognizes each one? What response occurs when a T cell recognizes what is being presented on MHC I? What happens if it recognizes MHC II? Give an example of each type of recognition.arrow_forwardWhich of the following is part of the T-cell clonal deletion process? a) T-cells are eliminated if they bind to B-cells b) Lymphocytes that bind to MHC undergo apoptosis c) T-cells that bind to the same antigen as B-cells are eliminated d) Lymphocytes that react to autoantigens undearrow_forwardWhich type of T cell is most important in both cellular and humoral immunity? Why?arrow_forward
- Which of the following pairs is mismatched? a. T-cell activation: cell division and differentiation b. effector B cell: plasma cell c. plasma cell: antibody secretion d. helper T cell: kills pathogen-infected cells e. helper T cell: facilitates the differentiation of B cells.arrow_forwardActivated helper T Cells participate in which of the following processes? a.) Differentiation of memory B cells b.) Activation of cytotoxic T Cells c.) Facilitation of macrophage phagocytosis d.) All of abovearrow_forwardWhat are the differences in the types of antigens recognized by antibodies and T cell receptors?arrow_forward
- Which of the following can serve as antigen-presenting cells (APCs)?a. T cells b. B cells c. macrophages d. dendritic cells e. b, c, and darrow_forwardIn general, what are consequences of activation of the TH1 arm of the immune response? Activation of the TH2 arm?arrow_forwardWhich of the following describes the developmental pathway for T cells? a. thymus → bone marrow → spleen b. thymus → bone marrow → thymus c. bone marrow → thymus → lymph nodes d. lymph nodes → thymus → spleen e. bone marrow → lymph nodes → thymus.arrow_forward
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