EBK BROCK BIOLOGY OF MICROORGANISMS
15th Edition
ISBN: 8220103633352
Author: Stahl
Publisher: PEARSON
expand_more
expand_more
format_list_bulleted
Textbook Question
Chapter 28, Problem 3AQ
Describe three important reasons why semisynthetic penicillins were first developed. Which clinical challenges does each of these reasons address? What key part of the penicillin molecule must be retained for any semisynthetic penicillin to be active?
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solutionStudents have asked these similar questions
The following structures were introduced as neuromuscular blocking agents.
Structure B is derived from structure A. What was the main reason for incorporating additional ester
groups?
O To enhance hydrogen bonding interactions with the binding site.
O To increase the polarity of the drug.
O To decrease the stability of the drug
O To alter the conformation of the molecule.
Which of the following statement is false regarding the SARS-CoV-2 protease Mpro?
a) Mpro catalyze the translation of viral RNA into polyproteins
b) Mpro is an ideal drug target because its structure is largely conserved across the SARS-CoV family
c) N3 is an irreversible inhibitor that block the substrate binding site of Mpro
d) Mpro forms a dimeric structure and each protomer is composed of three domains
Describe: a.) the mechanism of action of PF-07321332, the active compound
found in the antiviral drug Paxlovid; b.) the viral target that it inhibits; and c.) the
product formed. Use schemes where appropriate to support your answer.
H
H"
H
NH
NH
PF-07321332
F
Chapter 28 Solutions
EBK BROCK BIOLOGY OF MICROORGANISMS
Ch. 28.1 - The use of personal protective equipment (PPE) is...Ch. 28.1 - Identify and discuss the standard safety...Ch. 28.1 - Prob. 1CRCh. 28.2 - Prob. 1MQCh. 28.2 - How can the spread of HAIs be controlled?Ch. 28.2 - Prob. 1CRCh. 28.3 - What are the key points necessary for proper...Ch. 28.3 - Identify culture methods and conditions used for...Ch. 28.3 - QWhy is it important to process clinical specimens...Ch. 28.4 - Describe the disc diffusion test and the Etest for...
Ch. 28.4 - What is the value of antimicrobial drug...Ch. 28.4 - QDescribe the disc diffusion test for antibiotic...Ch. 28.5 - Explain the reasons for changes in antibody titer...Ch. 28.5 - Describe the method, time frame, and rationale for...Ch. 28.5 - What advantages do monoclonal antibodies have...Ch. 28.5 - QWhy does antibody titer rise after infection? Is...Ch. 28.6 - How is the bivalence of antibodies significant for...Ch. 28.6 - What are the advantages and disadvantages of...Ch. 28.6 - Why are agglutination tests so widely used in...Ch. 28.7 - Prob. 1MQCh. 28.7 - Compare the advantages and disadvantages of EIA,...Ch. 28.7 - Prob. 1CRCh. 28.8 - What advantage(s) does nucleic acid amplification...Ch. 28.8 - How do quantitative PCR (qPCR) and qualitative PCR...Ch. 28.8 - Distinguish between quantitative and qualitative...Ch. 28.9 - Compare and contrast live attenuated vaccines,...Ch. 28.9 - Identify the advantages of alternative...Ch. 28.9 - QList the immunizations recommended for children...Ch. 28.10 - Prob. 1MQCh. 28.10 - How does the activity of each antibiotic class...Ch. 28.10 - What are the sources of aminoglycosides,...Ch. 28.10 - Antibiotics are chemically diverse antimicrobial...Ch. 28.11 - What steps in the viral maturation process are...Ch. 28.11 - Why are there fewer clinically effective...Ch. 28.11 - Why is host toxicity a common problem with...Ch. 28.12 - Identify the basic mechanisms of antibiotic...Ch. 28.12 - What does vancomycin have in common with...Ch. 28.12 - Prob. 3MQCh. 28.12 - What practices contribute to the spread of...Ch. 28 - Define the procedures you would use to isolate and...Ch. 28 - Prob. 2AQCh. 28 - Describe three important reasons why semisynthetic...Ch. 28 - Imagine yourself as a clinical microbiologist with...
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- What is the molecular site of oligomycin action?arrow_forwardBeta-lactamase is the enzyme that confers penicillin resistance. How does Beta-lactamase renders penicillin inactive at its target site?arrow_forwardThe ribosome is the target for many important antibiotics. These drugs must discriminate between bacterial and eukaryotic ribosomes to achieve drug specificity and toxicity. For the two common antibiotics below, what is their mechanism of action and why are they more toxic to bacteria than eukaryotes? a) Tetracycline b) Erythromycinarrow_forward
- Give correct typing answer with explanation and conclusion to all partsarrow_forwardWhat are anticoagulants?What are the practicalapplications of anticoagulants,like heparin, in Medicine?arrow_forwardVarious antimicrobial drugs to treat microbial infection have diverse mechanism of action. Consider the following antimicrobial drugs: A. Seconeolitsine, known as DNA topoisomerase I inhibitor in bacteria. (i) Explain briefly how inhibiting DNA topoisomerase I is a good mechanism of action for an antibiotic, include possible molecular machineries being targeted. (ii) What would be an appropriate response if seconeolitsine works well by stating the state of supercoiling in bacteria. (iii) To prove your answer (ii), you test the condition of bacterial DNA by running gel electrophoresis, one has been treated with seconeolitsine (+ sample) and the other one is not (- sample). Explain the position of each + sample and – sample band on the gel in reference to the point of origin (where you load your samples) or how far each DNA sample travel across agarose gel. (iv) Explain why you would expect answer (iii) for each + sample and – sample. B.…arrow_forward
- Both ethanol and trimethyldodecylammonium chloride are active ingredients in cleaning products used to disinfect. Both will inactivate coronaviruses by a similar mechanism of action. Describe that mechanism of action and why both chemicals are able to cause it. (Reminder: coronaviruses are "lipid envelope" viruses.) Consider the physical properties of these compounds to answer the following question: why might you choose to use a cleaning product with one of these active ingredients over the other?arrow_forwardWhat is the underlying molecular mechanism of action for the antibiotic novobiocin?arrow_forwardWhich of the following can deaminate Adenine, changing it to hypoxanthine? A) base analogues B) intercalating agents C) UV light D) X-rays E) base modifiersarrow_forward
- You have isolated a beta-lactamase producing Staphylococcus aureus (not a MRSA strain) from an infected surgical site on your patient. If for genetic reasons, your patient is allergic to all antibiotics except beta-lactam antibiotics such as ampicillin ( they can only take Beta-lactam antibiotics such as ampicillin), which strategy below could you use to treat this Staphylococcus aureus infection in your patient? Note different answers compared to previous question. give the patient erythromycin can use a beta-lactamse resistant beta-lactam such as methicillin or oxacillin O give the patient penicillin give the patient an azole drugarrow_forwardWhat phrases do the CDC and other leading officials now use to describe the risk of contracting COVID-19 through surfaces?arrow_forwardWhy are two or more antitubercular medications used together to treat TB disease?arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
USMLE-Rx Antimicrobial Therapy; Author: USMLE-Rx;https://www.youtube.com/watch?v=Pka1Ynlrqtw;License: Standard Youtube License