HUMAN A&P E-TEXT ACCESS CODE
11th Edition
ISBN: 9780136849063
Author: Marieb
Publisher: PEARSON
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Chapter 29, Problem 11RQ
Summary Introduction
To review:
The pedigree and display the
Introduction:
Syndactyly refers to the condition in which two more digits are united together and is observed in mammals like siamang. This condition is an unusual condition in humans. This condition can be either complex or simple. In simple one, the neighboring fingers are connected soft tissue while in complex one, the bones of the nearby digits are joined. This condition is seen in Paul, his three brothers, his father, and his paternal grandmother.
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For decades scientists have been perplexed by different circumstances surrounding families with rare, early-onset auditory neuropathy (deafness). In some families, parents and grandparents of the proband have normal hearing, while in other families, a number of affected (deaf) family members are scattered throughout the pedigree, appearing in every generation. Assuming a genetic cause for each case, offer a reasonable explanation for the genetic origin of such deafness in the two types of families.
A couple wants to have a child, but the mother has a brother that is affected by cystic fibrosis. They seek out the advice of a genetic counselor at their local hospital to determine what, if any, chance they have of producing an offspring that has cystic fibrosis. During the discussion, the counselor finds out that the husband’s uncle (on his mother’s side) had cystic fibrosis as well. Build a pedigree to explain the genotypes of the father’s grandparents, the mother’s parents, and the mother’s brother. Is it possible, based on the pedigree analysis, for the couple to have a child affected by cystic fibrosis? Construct a Punnett square to support your answer. Hint: Certain assumptions must be made to answer this question definitively. If not, then the question is unable to be answered in a definitive way. Be sure to identify what assumptions must be made. (Think about the husband’s side.)
A standard three-point mapping is conducted for recessive mutations in autosomal genes purple eye (pr), curved wing ( c) and black body (b). Their wild type alleles are also used for genetic mapping. An F1 Drosophila female heterozygous for purple eye (pr), curved wing (c) and black (b) is crossed to a triply homozygous mutant male. The observed numbers and phenotypes of the offspring are as follows:
360 pr c b
380 pr+ c+ b+
104 pr c+ b
96 pr+ c b+
30 pr c b+
20 pr+ c+ b
6 pr c+ b+
4 pr+ c b
PROVIDE THE FOLLOWING:
A) State the order of genes on this chromosome.
B) Calculate map distances between the gene pairs: pr-c, pr-b, c-b. Show calculations, state the number of map units and which gene pairs they refer to.
Chapter 29 Solutions
HUMAN A&P E-TEXT ACCESS CODE
Ch. 29 - Match each of the following key terms (ai) with...Ch. 29 - 2. Match the following types of inheritance (key...Ch. 29 - Prob. 3RQCh. 29 - 4. The ability to taste PTC (phenylthiocarbamide)...Ch. 29 - Most children with cystic fibrosis are born to...Ch. 29 - 6. A woman with blood type A has two children. One...Ch. 29 - 7. In skin color inheritance, what will be the...Ch. 29 - 8. Compare and contrast amniocentesis and...Ch. 29 - Prob. 10RQCh. 29 - Prob. 11RQ
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- Pedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. 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Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. Would you want to know the results of the cancer, heart disease, and TSD tests if you were Sarah and Adam? Is it their responsibility as potential parents to gather this type of information before they decide to have a child?arrow_forwardPedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. 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Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. If Sarah carries the mutant cancer allele and Adam carries the mutant heart disease allele, what is the chance that they would have a child who is free of both diseases? Are these good odds?arrow_forwardA proband female with an unidentified disease seeks the advice of a genetic counselor before starting a family. 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- The following pedigree shows the pattern of inheritance of red-green color blindness in a family. Females are shown as circles and males as squares; the squares or circles of individuals affected by the trait are filled in black. What is the chance that a son of the third-generation female indicated by the arrow will be color blind if the father is not color blind? If he is color blind?arrow_forwardPedigree Analysis Is a Basic Method in Human Genetics Using the pedigree provided, answer the following questions. a. Is the proband male or female? b. Is the grandfather of the proband affected? c. How many siblings does the proband have, and where is he or she in the birth order?arrow_forwardTwo autosomal mutations include albinism and dwarfism. Albinism (a) is recessive, and dwarfism (D) is dominant. Complete a dihybrid cross of two people that are heterozygous for normal pigmented skin. One person is normal height and has no genetic trace of dwarfism in the family. The other person has dwarfism but has a mother who is normal height. 21. Complete a full dihybrid Punnett square (6pts).arrow_forward
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