Chapter 3, Problem 1M

Problem 3. If a woman is hemophiliac, she will give birth to only hemophiliac sons regardless of the genotype of the father. Construct a Punnett squares to confirm this. There should be two of them. a) Construct a Punnett Square - List gametes in the area with the dashed line and the genotypes of the offspring in the area with the sold line.     b) Construct a Punnett Square - List gametes in the area with the dashed line and the genotypes of the offspring in the area with the sold line. Please show with BOTH PUNNETT SQUARES THERE SHOULD BE TWO!!!!

Problem 3. If a woman is hemophiliac, she will give birth to only hemophiliac sons regardless of the genotype of the father. Construct a Punnett squares to confirm this. There should be two of them. a) Construct a Punnett Square - List gametes in the area with the dashed line and the genotypes of the offspring in the area with the solid line.     b) Construct a Punnett Square - List gametes in the area with the dashed line and the genotypes of the offspring in the area with the solid line.

Topic: Recombinant pharmaceuticals (for the production of insulin, human growth hormone or blood clotting factors) Questions: Give a research scientist (not a company) who laid the foundation for this process OR is currently working in an area involving this process.

Horizontal sequence :VIRL Vertical sequence:MKF   Scoring rules: g/o = -3, g/e = -1, match or mismatch - from PAM250 substitution matrix below.  NW algorithm.    1. Complete the scoring matrix.    Scoring matrix with PAM250 scores:   V I R L M         K         F           2. Set up, initialize and complete the NW matrix.  3. Retrace, align and score alignment(s).             Use the arrows and circles for the matrix and path(s).                                                                                                                                                                                                                                                                                                                                 V I R L             M           K           F           Align and score all optimal alignments here.  PLZ  the arrows and circles for the matrix and path(s) AND SHOW ALL possible Alignment

Breast Cancer Screening Program – A group of women were subjected to a breast cancer screening program. A newly developed screening test was utilized to measure its sensitivity and specificity against a gold standard test.   a) What is the prevalence of breast cancer in this population? b) Calculate the Sensitivity of the test and provide interpretation c) Calculate the Specificity of the test and provide interpretation

What are the potential negative reasons that exist when utilizing DTC genomic tests with respect to the analysis of an individual's health? Could large scale, or mass testing, projects solve these drawbacks?   asap please

Horizontal sequence :VIRL Vertical sequence:MKF   Scoring rules: g/o = -3, g/e = -1, match or mismatch - from PAM250 substitution matrix below.  SW algorithm.    1. Complete the scoring matrix.    Scoring matrix with PAM250 scores:   V I R L M         K         F           2. Set up, initialize and complete the SW matrix.  3. Retrace, align and score alignment(s).             Use the arrows and circles for the matrix and path(s).                                                                                                                                                                                                                                                                                                                                 V I R L             M           K           F           Align and score all optimal alignments here.  PLZ  the arrows and circles for the matrix and path(s) AND SHOW ALL possible Alignment

Horizontal sequence :VIRL Vertical sequence:MKF   Scoring rules: g/o = -3, g/e = -1, match or mismatch - from PAM250 substitution matrix below.    SW algorithm.    1. Complete the scoring matrix.    Scoring matrix with PAM250 scores:     V I R L M         K         F           2. Set up, initialize and complete the SW matrix.  3. Retrace, align and score alignment(s).             Use the arrows and circles for the matrix and path(s).                                                                                                                                                                                                                                                                                                                                 V I R L             M           K           F             Align and score all optimal alignments here.

Genetics in Practice case studies are critical-thinking exercises that allow you to apply your new knowledge of human genetics to real-life problems. Case study Michelle was a 42-year-old woman who had declined counselling and amniocentesis at 16 weeks of pregnancy but was referred for genetic counseling after an abnormal ultrasound at 20 weeks of gestation. After the ultrasound, a number of findings suggested a possible chromosome abnormality in the fetus. The ultrasound showed swelling under the skin at the back of the fetuss neck; shortness of the femur, humerus, and ear length; and underdevelopment of the middle section of the fifth finger. Michelles physician performed an amniocentesis and referred her to the genetics program. Michelle and her husband did not want genetic counseling before receiving the results of the cytogenetic analysis. This was Michelles third pregnancy; she and her husband, Mike, had a 6-year-old daughter and a 3-year-old son. At their next session, the counselor informed the couple that the results revealed trisomy 21, explored their understanding of Down syndrome, and elicited their experiences with people with disabilities. She also reviewed the clinical concerns revealed by the ultrasound and associated anomalies (mild to severe intellectual disability, cardiac defects, and kidney problems). The options available to the couple were outlined. They were provided with a booklet written for parents making choices after the prenatal diagnosis of Down syndrome. After a week of careful deliberation with their family, friends, and clergy, they elected to terminate the pregnancy. Should physicians discourage a 42-year-old woman from having children because of an increased chance of a chromosomal abnormality?