Concept explainers
For each pedigree shown,
a. Identify which simple pattern of hereditary trans-mission (autosomal dominant, autosomal recessive, X-linked dominant, or X-linked recessive) is most likely to have occurred. Give genotypes for individuals involved in transmitting the trait.
b. Determine which other pattern(s) of transmission is/are possible. For each possible mode of transmission, specify the genotypes necessary for transmission to occur.
c. Identify which pattern(s) of transmission is/are impossible. Specify why transmission is impossible.
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Chapter 3 Solutions
GENETIC ANALYSIS: INTEGRATED - ACCESS
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- Ill.siven the following pedigree below, use Punnett squares for each of the following possibilities: a) X- linked dominant, b) X-linked recessive, c) Autosomal dominant and d) Autosomal recessive in order to determine what is the mode of transmission of this trait. Disease allele = Xª, x², A or a depending on mode of transmission of the disease respectively. Unaffected X chromosome = X *Homozygous unaffected/No 1 *2 carrier=Normal II 1 *4 1 2 3 6. 7 8 a) X-linked dominant 11x12 b) X-linked recessive I 1 x1 2 c) Autosomal dominant 11x12 d) Autosomal recessive I1x12 IV. Based on your analysis what is the mode of transmission for this disease? O+arrow_forwardE. D. A. B. 11. C. Huntington's disease is a degenerative disease of the nervous system that strikes in middle age. The allele that causes the disease (H) is dominant to the allele that results in the normal condition (h). Answer the following questions about the inheritance of this disease. What is the genotype of a man who is normal but whose father had Huntington's disease? What is the genotype of a woman who has Huntington's disease if both of her parents had Huntington's disease? If a man who is heterozygous for Huntington's disease marries a woman who is normal, what would you expect for the genotypes and phenotypes of their children? If a normal man marries a woman who is homozygous for Huntington's disease, what do you expect for the genotypes and phenotypes of their children? Since Huntington's disease is caused by a dominant allele, does this mean it's also the most common allele in the population? F. Since Huntington's disease is caused by a dominant allele, does this mean…arrow_forwardFaulty Tooth Enamel Formation Amelogenesis imperfecta (AI) is a disorder of faulty tooth enamel formation. It is inherited in an autosomal dominant and X-linked dominant pattern. The expression of AI disorder is determined by mutations in the autosomal alleles. One copy of the mutated allele (A) will cause the disorder. The severity of the disorder is determined by mutations in a gene carried on the X chromosome. Normal (or non-severe) abnormality (XN) is dominant over the abnormality (or severe) (Xn) allele. In the absence of the autosomal dominant allele, the abnormality gene on the X chromosome is notexpressed. Question:A woman with normal teeth had four children with a man with non-severe form of AI: A boy was born without amelogenesis imperfecta A girl was born without amelogenesis imperfecta A boy was born with severe amelogenesis imperfecta A boy was born with non severe amelogenesis imperfecta Identify the parental genotypes. Complete the Punnett square for the parental…arrow_forward
- A. How does the structure of a Barr body affect gene expression? B. Color-blindness is an X-linked recessive trait. Heterozygous females are not color blind but they can sometimes have partial color blindness. Explain how this can occur.arrow_forwardAmelogenesis imperfecta (AI) is a disorder of faulty tooth enamel formation. It is inherited in an autosomal dominant and X-linked dominant pattern. The expression of AI disorder is determined by mutations in the autosomal alleles. One copy of the mutated allele (A) will cause the disorder. The severity of the disorder is determined by mutations in a gene carried on the X chromosome. Normal (or non-severe) abnormality (XN) is dominant over the abnormality (or severe) (Xn) allele. In the absence of the autosomal dominant allele, the abnormality gene on the X chromosome is notexpressed. Question:A woman with normal teeth had four children with a man with non-severe form of AI: A boy was born without amelogenesis imperfecta A girl was born without amelogenesis imperfecta A boy was born with severe amelogenesis imperfecta A boy was born with non severe amelogenesis imperfecta Identify the parental genotypes. Complete the Punnett square for the parental cross, and identify the possible…arrow_forwardAmelogenesis imperfecta (AI) is a disorder of faulty tooth enamel formation. It is inherited in an autosomal dominant and X-linked dominant pattern. The expression of AI disorder is determined by mutations in the autosomal alleles. One copy of the mutated allele (A) will cause the disorder. The severity of the disorder is determined by mutations in a gene carried on the X chromosome. Normal (or non-severe) abnormality (XN) is dominant over the abnormality (or severe) (Xn) allele. In the absence of the autosomal dominant allele, the abnormality gene on the X chromosome is not expressed. Question:A woman with normal teeth had four children with a man with non-severe form of AI: A boy was born without amelogenesis imperfecta A girl was born without amelogenesis imperfecta A boy was born with severe amelogenesis imperfecta A boy was born with non severe amelogenesis imperfecta Identify the parental genotypes. Complete the Punnett square for the parental cross, and identify the…arrow_forward
- A. Identify the most likely inheritance pattern in the pedigree below. B. What are the genotypes of individuals II-3 and Il-4? Use any letter for your example. 1 2 II 1 2 3 4 5 II 1 2 3 4 5 6arrow_forwardAmelogenesis imperfecta (AI) is a disorder of faulty tooth enamel formation. It is inherited in an autosomal dominant and X-linked dominant pattern. The expression of AI disorder is determined by mutations in the autosomal alleles. One copy of the mutated allele (A) will cause the disorder. The severity of the disorder is determined by mutations in a gene carried on the X chromosome. Normal (or non-severe) abnormality (XN) is dominant over the abnormality (or severe) (Xn) allele. In the absence of the autosomal dominant allele, the abnormality gene on the X chromosome is not expressed. Question:A woman with normal teeth had four children with a man with non-severe form of AI: A boy was born without amelogenesis imperfecta A girl was born without amelogenesis imperfecta A boy was born with severe amelogenesis imperfecta A boy was born with non severe amelogenesis imperfecta Identify the parental genotypes. Complete the Punnett square for the parental cross, and identify the…arrow_forward1) Symptoms of 4 disorders are listed. Using the lists given, fill in the correct letter for the condition name and inheritance type. Letters may be used more than once. Symptoms Condition Inheritance Туре Loss of muscle control and decline in mental ability Shades of red and green are hard to distinguish Lack of skin pigmentation Cannot produce one of the necessary blood clotting factors Conditions: Inheritance Type: A: Albinism E: X-linked dominant B: Huntington Disease F: X-linked recessive G: Y-linked C: Hemophilia H: Autosomal dominant I: Autosomal recessive D: CVDarrow_forward
- A. Identify the type of inheritance from the given options below. Write only the letters of your answer, i.e. AD for autosomal dominant.Autosomal Dominant Autosomal Recessive X-Linked Recessive Y-Linked B. Give the possible genotype of the AFFECTED individuals. In indicating the genotype of affected individual, specify the generation and number where the individual belongs, i.e. II-3 AA; III-1 aa See attached image.arrow_forwarda. What are the other systems of blood typing? What are the modes of inheritance of these groups? Fill up the table. BLOOD GROUPS MODE OF INHERITANCE b. What are the applications of the genetics of blood typing? List at least three.arrow_forwardIdentify the specific mode of inheritance. 1.) Mae is affected with the disease phenylketonuria (PKU). The PKU gene codes for the production of the enzyme that metabolizes phenylalanine. Nonfunctionality of this gene can lead to intellectual disability, seizures, and other serious medical problems. 2.) Duchenne muscular dystrophy results from the mutation of the dystrophin gene. While both sexes carry the mutation, females rarely exhibit signs of the disease.arrow_forward
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